Identification of Potential Drug Targets Implicated in Parkinson's Disease from Human Genome : Insights of Using Fused Domains in Hypothetical Proteins as Probes
Joint Authors
Khanduja, Varun
Nirmala, K. A.
Rathankar, N.
Nagendra, H. G.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
High-throughput genome sequencing has led to data explosion in sequence databanks, with an imbalance of sequence-structure-function relationships, resulting in a substantial fraction of proteins known as hypothetical proteins.
Functions of such proteins can be assigned based on the analysis and characterization of the domains that they are made up of.
Domains are basic evolutionary units of proteins and most proteins contain multiple domains.
A subset of multidomain proteins is fused domains (overlapping domains), wherein sequence overlaps between two or more domains occur.
These fused domains are a result of gene fusion events and their implication in diseases is well established.
Hence, an attempt has been made in this paper to identify the fused domain containing hypothetical proteins from human genome homologous to parkinsonian targets present in KEGG database.
The results of this research identified 18 hypothetical proteins, with domains fused with ubiquitin domains and having homology with targets present in parkinsonian pathway.
American Psychological Association (APA)
Rathankar, N.& Nirmala, K. A.& Khanduja, Varun& Nagendra, H. G.. 2011. Identification of Potential Drug Targets Implicated in Parkinson's Disease from Human Genome : Insights of Using Fused Domains in Hypothetical Proteins as Probes. ISRN Neurology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-458722
Modern Language Association (MLA)
Rathankar, N.…[et al.]. Identification of Potential Drug Targets Implicated in Parkinson's Disease from Human Genome : Insights of Using Fused Domains in Hypothetical Proteins as Probes. ISRN Neurology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-458722
American Medical Association (AMA)
Rathankar, N.& Nirmala, K. A.& Khanduja, Varun& Nagendra, H. G.. Identification of Potential Drug Targets Implicated in Parkinson's Disease from Human Genome : Insights of Using Fused Domains in Hypothetical Proteins as Probes. ISRN Neurology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-458722
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458722