Diffusion Tensor Imaging in NAWM and NADGM in MS and CIS : Association with Candidate Biomarkers in Sera
Joint Authors
Wu, Xingchen
Hakulinen, Ullamari
Hagman, Sanna
Rossi, Maija
Raunio, Minna
Elovaara, Irina
Natarajan, Renuka
Helminen, Mika
Dastidar, Prasun
Source
Multiple Sclerosis International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of this study was to evaluate diffusion tensor imaging (DTI) indices in the corpus callosum and pyramidal tract in normal-appearing white matter (NAWM) and the caudate nucleus and thalamus in deep grey matter (NADGM) in all MS subtypes and clinically isolated syndrome (CIS).
Furthermore, it was determined whether these metrics are associated with clinical measures and the serum levels of candidate immune biomarkers.
Apparent diffusion coefficients (ADC) values were significantly higher than in controls in all six studied NAWM regions in SPMS, 4/6 regions in RRMS and PPMS and 2/6 regions in CIS.
In contrast, decreased fractional anisotropy (FA) values in comparison to controls were detected in 2/6 NAWM regions in SPMS and 1/6 in RRMS and PPMS.
In RRMS, the level of neurological disability correlated with thalamic FA values (r=0.479, P=0.004).
In chronic progressive subtypes and CIS, ADC values of NAWM and NADGM were associated with the levels of MIF, sFas, and sTNF-α.
Our data indicate that DTI may be useful in detecting pathological changes in NAWM and NADGM in MS patients and that these changes are related to neurological disability.
American Psychological Association (APA)
Natarajan, Renuka& Hagman, Sanna& Wu, Xingchen& Hakulinen, Ullamari& Raunio, Minna& Helminen, Mika…[et al.]. 2013. Diffusion Tensor Imaging in NAWM and NADGM in MS and CIS : Association with Candidate Biomarkers in Sera. Multiple Sclerosis International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-458723
Modern Language Association (MLA)
Natarajan, Renuka…[et al.]. Diffusion Tensor Imaging in NAWM and NADGM in MS and CIS : Association with Candidate Biomarkers in Sera. Multiple Sclerosis International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-458723
American Medical Association (AMA)
Natarajan, Renuka& Hagman, Sanna& Wu, Xingchen& Hakulinen, Ullamari& Raunio, Minna& Helminen, Mika…[et al.]. Diffusion Tensor Imaging in NAWM and NADGM in MS and CIS : Association with Candidate Biomarkers in Sera. Multiple Sclerosis International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-458723
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458723