Paraoxonase Activity and Expression Is Modulated by Therapeutics in Experimental Rat Nonalcoholic Fatty Liver Disease
Joint Authors
Karry, R.
Abu Jabal, K.
Szvalb, S.
Bersudsky, I.
Grozovski, M.
Shams, I.
Aviram, Michael
Zidan, J. M.
Hussein, O.
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
The objective of the present study is to investigate the effect of rosiglitazone, metformin, ezetimibe, and valsartan (alone or in combinations) on paraoxonase (PON) activity and PON-mRNA expression in nonalcoholic fatty liver disease (NAFLD).
Methods.
54 Male Sprague–Dawley rats were divided to 9 groups: chow diet group (15 weeks); methionine-choline-deficient diet (MCDD) group (15 weeks); MCDD-treated groups for the last 6 weeks with either metformin (M), rosiglitazone (R), metformin plus rosiglitazone (M+R), ezetimibe (E), valsartan (V), or a combination of R+M+V or of R+M+V+E for a total period of 15 weeks.
Results.
PON activities in serum and liver were decreased in MCDD rats.
PON activity in serum increased significantly in all treatment groups.
PON activity in liver was also increased significantly, except only in groups R, E, V, R+M+V, and R+M+V+E.
Liver PON3 mRNA expression increased significantly in groups R+M, E, V, R+M+V, and R+M+V+E whereas liver PON2 mRNA expression increased significantly in MCDD, R+M, E, V, R+M+V, and R+M+V+E.
Conclusions.
PON activities in serum and liver were decreased in NAFLD.
Treatment with insulin sensitizers, ezetimibe, and valsartan increased PON activity and reduced oxidative stress both in serum and liver.
American Psychological Association (APA)
Hussein, O.& Zidan, J. M.& Abu Jabal, K.& Shams, I.& Szvalb, S.& Grozovski, M.…[et al.]. 2012. Paraoxonase Activity and Expression Is Modulated by Therapeutics in Experimental Rat Nonalcoholic Fatty Liver Disease. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-458727
Modern Language Association (MLA)
Hussein, O.…[et al.]. Paraoxonase Activity and Expression Is Modulated by Therapeutics in Experimental Rat Nonalcoholic Fatty Liver Disease. International Journal of Hepatology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-458727
American Medical Association (AMA)
Hussein, O.& Zidan, J. M.& Abu Jabal, K.& Shams, I.& Szvalb, S.& Grozovski, M.…[et al.]. Paraoxonase Activity and Expression Is Modulated by Therapeutics in Experimental Rat Nonalcoholic Fatty Liver Disease. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-458727
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458727