Drug Management of Visceral Pain : Concepts from Basic Research
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-24
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Visceral pain is experienced by 40% of the population, and 28% of cancer patients suffer from pain arising from intra- abdominal metastasis or from treatment.
Neuroanatomy of visceral nociception and neurotransmitters, receptors, and ion channels that modulate visceral pain are qualitatively or quantitatively different from those that modulate somatic and neuropathic pain.
Visceral pain should be recognized as distinct pain phenotype.
TRPV1, Na 1.8, and ASIC3 ion channels and peripheral kappa opioid receptors are important mediators of visceral pain.
Mu agonists, gabapentinoids, and GABAB agonists reduce pain by binding to central receptors and channels.
Combinations of analgesics and adjuvants in animal models have supra-additive antinociception and should be considered in clinical trials.
This paper will discuss the neuroanatomy, receptors, ion channels, and neurotransmitters important to visceral pain and provide a basic science rationale for analgesic trials and management.
American Psychological Association (APA)
Davis, Mellar P.. 2012. Drug Management of Visceral Pain : Concepts from Basic Research. Pain Research and Treatment،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-458745
Modern Language Association (MLA)
Davis, Mellar P.. Drug Management of Visceral Pain : Concepts from Basic Research. Pain Research and Treatment No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-458745
American Medical Association (AMA)
Davis, Mellar P.. Drug Management of Visceral Pain : Concepts from Basic Research. Pain Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-458745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458745