Mesenchymal Stem Cells in Immune-Mediated Bone Marrow Failure Syndromes
Joint Authors
Pavlaki, Konstantia
Pontikoglou, Charalampos
Batsali, Aristea K.
Kouvidi, Elisavet
Papadaki, Helen A.
Kastrinaki, Maria-Christina
Mavroudi, Irene
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Immune-mediated bone marrow failure syndromes (BMFS) are characterized by ineffective marrow haemopoiesis and subsequent peripheral cytopenias.
Ineffective haemopoiesis is the result of a complex marrow deregulation including genetic, epigenetic, and immune-mediated alterations in haemopoietic stem/progenitor cells, as well as abnormal haemopoietic-to-stromal cell interactions, with abnormal release of haemopoietic growth factors, chemokines, and inhibitors.
Mesenchymal stem/stromal cells (MSCs) and their progeny (i.e., osteoblasts, adipocytes, and reticular cells) are considered as key cellular components of the bone marrow haemopoietic niche.
MSCs may interfere with haemopoietic as well as immune regulation.
Evidence suggests that bone marrow MSCs may be involved in immune-mediated BMFS underlying pathophysiology, harboring either native abnormalities and/or secondary defects, caused by exposure to activated marrow components.
This review summarizes previous as well as more recent information related to the biologic/functional characteristics of bone marrow MSCs in myelodysplastic syndromes, acquired aplastic anemia, and chronic idiopathic neutropenia.
American Psychological Association (APA)
Kastrinaki, Maria-Christina& Pavlaki, Konstantia& Batsali, Aristea K.& Kouvidi, Elisavet& Mavroudi, Irene& Pontikoglou, Charalampos…[et al.]. 2013. Mesenchymal Stem Cells in Immune-Mediated Bone Marrow Failure Syndromes. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-458747
Modern Language Association (MLA)
Kastrinaki, Maria-Christina…[et al.]. Mesenchymal Stem Cells in Immune-Mediated Bone Marrow Failure Syndromes. Clinical and Developmental Immunology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-458747
American Medical Association (AMA)
Kastrinaki, Maria-Christina& Pavlaki, Konstantia& Batsali, Aristea K.& Kouvidi, Elisavet& Mavroudi, Irene& Pontikoglou, Charalampos…[et al.]. Mesenchymal Stem Cells in Immune-Mediated Bone Marrow Failure Syndromes. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-458747
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458747