Preparation, Characterization and Evaluation of Quetiapine Fumarate Solid Lipid Nanoparticles to Improve the Oral Bioavailability
Joint Authors
Narala, Arjun
Veerabrahma, Kishan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Economics & Business Administration
Pharmacology
Abstract EN
Quetiapine fumarate is an antipsychotic drug with poor oral bioavailability (9%) due to first-pass metabolism.
Present work is an attempt to improve oral bioavailability of quetiapine fumarate by incorporating in solid lipid nanoparticles (SLN).
Six quetiapine fumarate SLN formulations were developed using three different lipids by hot homogenisation followed by ultrasonication.
The drug excipient compatibility was studied by differential scanning calorimetry (DSC).
Stable quetiapine fumarate SLNs having a mean particle size of 200–250 nm with entrapment efficiency varying in between 80% and 92% were developed.
The physical stability of optimized formulation F3 was checked at room temperature for 2 months.
Comparative bioavailability studies were conducted in male Wistar rats after oral administration of quetiapine fumarate suspension and SLN formulation.
The relative bioavailability of quetiapine fumarate from optimized SLN preparation was increased by 3.71 times when compared with the reference quetiapine fumarate suspension.
The obtained results are indicative of SLNs as potential lipid carriers for improving the bioavailability of quetiapine fumarate by minimizing first-pass metabolism.
American Psychological Association (APA)
Narala, Arjun& Veerabrahma, Kishan. 2013. Preparation, Characterization and Evaluation of Quetiapine Fumarate Solid Lipid Nanoparticles to Improve the Oral Bioavailability. Journal of Pharmaceutics،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-458761
Modern Language Association (MLA)
Narala, Arjun& Veerabrahma, Kishan. Preparation, Characterization and Evaluation of Quetiapine Fumarate Solid Lipid Nanoparticles to Improve the Oral Bioavailability. Journal of Pharmaceutics No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-458761
American Medical Association (AMA)
Narala, Arjun& Veerabrahma, Kishan. Preparation, Characterization and Evaluation of Quetiapine Fumarate Solid Lipid Nanoparticles to Improve the Oral Bioavailability. Journal of Pharmaceutics. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-458761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458761