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Immunosenescence, Aging, and Systemic Lupus Erythematous
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-24
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Senescence is a normal biological process that occurs in all organisms and involves a decline in cell functions.
This process is caused by molecular regulatory machinery alterations, and it is closely related to telomere erosion in chromosomes.
In the context of the immune system, this phenomenon is known as immunosenescence and refers to the immune function deregulation.
Therefore, functions of several cells involved in the innate and adaptive immune responses are severely compromised with age progression (e.g., changes in lymphocyte subsets, decreased proliferative responses, chronic inflammatory states, etc.).
These alterations make elderly individuals prone to not only infectious diseases but also to malignancy and autoimmunity.
This review will explore the molecular aspects of processes related to cell aging, their importance in the context of the immune system, and their participation in elderly SLE patients.
American Psychological Association (APA)
Montoya-Ortiz, Gladys. 2013. Immunosenescence, Aging, and Systemic Lupus Erythematous. Autoimmune Diseases،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-458785
Modern Language Association (MLA)
Montoya-Ortiz, Gladys. Immunosenescence, Aging, and Systemic Lupus Erythematous. Autoimmune Diseases No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-458785
American Medical Association (AMA)
Montoya-Ortiz, Gladys. Immunosenescence, Aging, and Systemic Lupus Erythematous. Autoimmune Diseases. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-458785
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458785