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Distribution of Extrasynaptic NMDA Receptors on Neurons
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
NMDA receptors are found in both synaptic and extrasynaptic locations on neurons.
NMDA receptors also can be found on neurons in early stages prior to synaptogenesis, where they may be involved in migration and differentiation.
Extrasynaptic NMDA receptors typically are associated with contacts with adjacent processes such as axons and glia.
Extrasynaptic NMDA receptor clusters vary in size and may form associations with scaffolding proteins such as PSD-95 and SAP102.
The best-characterized extrasynaptic NMDA receptors contain NR1 and NR2B subunits.
Extrasynaptic NMDA receptors may be activated by glutamate spillover from synapses or from ectopic release of glutamate.
Consequently, extrasynaptic NMDA receptor activation may occur under different circumstances than that for synaptic NMDA receptors, indicating different functional consequences for the neuron.
In some cases, activation of extrasynaptic NMDA receptors may have a negative influence on the neuron, leading to cell damage and death, as may occur in some major diseases of the nervous system.
American Psychological Association (APA)
Petralia, Ronald S.. 2012. Distribution of Extrasynaptic NMDA Receptors on Neurons. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-458792
Modern Language Association (MLA)
Petralia, Ronald S.. Distribution of Extrasynaptic NMDA Receptors on Neurons. The Scientific World Journal No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-458792
American Medical Association (AMA)
Petralia, Ronald S.. Distribution of Extrasynaptic NMDA Receptors on Neurons. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-458792
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458792