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Undifferentiated Spindle-Cell Carcinoma of the Gallbladder : A Report of a Case, an Immunohistochemistry Profile, and a Review of the Literature
Joint Authors
Oreiby, Hanan Abdulhafez
Fahad Al Rashid, Fawaz
Salah Seada, Laila
Badmos, Kabir Bolarinwa
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-13
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Undifferentiated spindle-cell carcinoma is a rare gallbladder cancer with a worse or similar prognosis to the generally dismal outcome seen in most gallbladder cancer patients.
We reported a case of SpCC, stage IV disease that was initially diagnosed as undifferentiated pleomorphic sarcoma, but deeper sections revealed few clusters of epithelioid clear cells.
Although the tumour showed biphasic appearances on haematoxylin and eosin, it exhibited poor protein expression with most sarcoma markers being negative except for focal vimentin positivity.
The CEA and CK7 were positive only in the epithelioid clear cell clusters while CD 68 positive was also focally positive in the spindle-cell component.
The poor tumour differentiation coupled with advanced stage at presentation was partly responsible for the disease progression and patients' death one year after surgery.
Early diagnosis and surgical intervention with better understanding of this tumour biology may offer improved prognosis and survival in this rare cancer.
American Psychological Association (APA)
Badmos, Kabir Bolarinwa& Salah Seada, Laila& Fahad Al Rashid, Fawaz& Oreiby, Hanan Abdulhafez. 2013. Undifferentiated Spindle-Cell Carcinoma of the Gallbladder : A Report of a Case, an Immunohistochemistry Profile, and a Review of the Literature. Case Reports in Pathology،Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-458802
Modern Language Association (MLA)
Badmos, Kabir Bolarinwa…[et al.]. Undifferentiated Spindle-Cell Carcinoma of the Gallbladder : A Report of a Case, an Immunohistochemistry Profile, and a Review of the Literature. Case Reports in Pathology No. 2013 (2013), pp.1-3.
https://search.emarefa.net/detail/BIM-458802
American Medical Association (AMA)
Badmos, Kabir Bolarinwa& Salah Seada, Laila& Fahad Al Rashid, Fawaz& Oreiby, Hanan Abdulhafez. Undifferentiated Spindle-Cell Carcinoma of the Gallbladder : A Report of a Case, an Immunohistochemistry Profile, and a Review of the Literature. Case Reports in Pathology. 2013. Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-458802
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458802