Simulation of the Frank-Starling Law of the Heart
Joint Authors
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
We developed a lumped parameter, computer-based model of an equivalent electronic circuit for a one-atrium one-ventricle (frog) heart attached to a vascular circuit, to simulate a basic concept of cardiovascular physiology, the Frank-Starling Law of the Heart.
A series of simulations was performed, to observe changes in cardiovascular variables (e.g., arterial pressure, ventricular volume, and valve flows) if either preload or afterload was increased.
The simulated data agreed qualitatively, and quantitatively when experimental data are available, with data obtained on amphibian or on mammalian myocardium.
In addition, the data obtained in these simulations improve our understanding of the mechanism(s) whereby the heart muscle adapts itself to increased distension (increased preload) or to impeded systolic contraction (increased afterload).
The analysis of the measured valve flows suggests that the ventricle is a highly input sensitive pump because the input pressure determines the diastolic distension and, consequently, the force of ventricular systolic contraction.
On the other hand, the ventricle is a relatively output insensitive pump.
Therefore, not only atrium contraction, but also predominantly the preceding ventricular systolic contraction is the main mechanism of the subsequent diastolic ventricular filling.
We conclude that the presented model enables the study of basic concepts of cardiovascular physiology.
American Psychological Association (APA)
Ribarič, Samo& Kordaš, Marjan. 2012. Simulation of the Frank-Starling Law of the Heart. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-458865
Modern Language Association (MLA)
Ribarič, Samo& Kordaš, Marjan. Simulation of the Frank-Starling Law of the Heart. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-458865
American Medical Association (AMA)
Ribarič, Samo& Kordaš, Marjan. Simulation of the Frank-Starling Law of the Heart. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-458865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458865