Comparative Study of the Effect of Baicalin and Its Natural Analogs on Neurons with Oxygen and Glucose Deprivation Involving Innate Immune Reaction of TLR2TNFα
Joint Authors
Zhao, Shuang
Lei, Fan
Ding, Yi
Li, Hui-Ying
Wan, Hong-Jiao
Du, Li-Jun
Hu, Jun
Xing, Dong-Ming
Yuan, Zhi-Yi
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This work is to study the baicalin and its three analogs, baicalin, wogonoside, and wogonin, on the protective effect of neuron from oxygen-glucose deprivation (OGD) and toll-like receptor 2 (TLR2) expression in OGD damage.
The results showed that baicalin and its three analogs did protect neurons from OGD damage and downregulated protein level of TLR2.
D-Glucopyranosiduronic acid on site 7 in the structure played a core of cytotoxicity of these flavonoid analogs.
The methoxyl group on carbon 8 of the structure had the relation with TLR2 protein expression, as well as the anti-inflammation.
In addition, we detected caspase3 and antioxidation capability, to investigate the effect of four analogs on cell apoptosis and total antioxidation competence in OGD model.
American Psychological Association (APA)
Li, Hui-Ying& Hu, Jun& Zhao, Shuang& Yuan, Zhi-Yi& Wan, Hong-Jiao& Lei, Fan…[et al.]. 2012. Comparative Study of the Effect of Baicalin and Its Natural Analogs on Neurons with Oxygen and Glucose Deprivation Involving Innate Immune Reaction of TLR2TNFα. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-458873
Modern Language Association (MLA)
Li, Hui-Ying…[et al.]. Comparative Study of the Effect of Baicalin and Its Natural Analogs on Neurons with Oxygen and Glucose Deprivation Involving Innate Immune Reaction of TLR2TNFα. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-458873
American Medical Association (AMA)
Li, Hui-Ying& Hu, Jun& Zhao, Shuang& Yuan, Zhi-Yi& Wan, Hong-Jiao& Lei, Fan…[et al.]. Comparative Study of the Effect of Baicalin and Its Natural Analogs on Neurons with Oxygen and Glucose Deprivation Involving Innate Immune Reaction of TLR2TNFα. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-458873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458873