Baicalin Inhibits IL-17-Mediated Joint Inflammation in Murine Adjuvant-Induced Arthritis
Joint Authors
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
T-helper-17 (Th17) cells are implicated in a number of inflammatory disorders including rheumatoid arthritis.
Antagonism of Th17 cells is a treatment option for arthritis.
Here, we report that Baicalin, a compound isolated from the Chinese herb Huangqin (Scutellaria baicalensis Georgi), relieved ankle swelling and protected the joint against inflammatory destruction in a murine adjuvant-induced arthritis model.
Baicalin inhibited splenic Th17 cell population expansion in vivo.
Baicalin prevented interleukin- (IL-) 17-mediated lymphocyte adhesion to cultured synoviocytes.
Baicalin also blocked IL-17-induced intercellular adhesion molecule 1, vascular cell adhesion molecule 1, IL-6, and tumor necrosis factor-alpha mRNA expression in cultured synoviocytes.
Collectively, these findings suggest that Baicalin downregulates the joint inflammation caused by IL-17, which is likely produced by an expanded population of splenic Th17 cells in experimental arthritis.
Baicalin might be a promising novel therapeutic agent for treating rheumatoid arthritis in humans.
American Psychological Association (APA)
Yang, Xue& Yang, Ji& Zou, He-Jian. 2013. Baicalin Inhibits IL-17-Mediated Joint Inflammation in Murine Adjuvant-Induced Arthritis. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-458888
Modern Language Association (MLA)
Yang, Xue…[et al.]. Baicalin Inhibits IL-17-Mediated Joint Inflammation in Murine Adjuvant-Induced Arthritis. Clinical and Developmental Immunology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-458888
American Medical Association (AMA)
Yang, Xue& Yang, Ji& Zou, He-Jian. Baicalin Inhibits IL-17-Mediated Joint Inflammation in Murine Adjuvant-Induced Arthritis. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-458888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458888