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Minimal Change Disease and IgA Deposition : Separate Entities or Common Pathophysiology?
Joint Authors
Wu, Ming
Mattoo, Aditya
Goldfarb, David S.
Oberweis, Brandon S.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-21
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Introduction.
Minimal Change Disease (MCD) is the most common cause of nephrotic syndrome in children, while IgA nephropathy is the most common cause of glomerulonephritis worldwide.
MCD is responsive to glucocorticoids, while the role of steroids in IgA nephropathy remains unclear.
We describe a case of two distinct clinical and pathological findings, raising the question of whether MCD and IgA nephropathy are separate entities or if there is a common pathophysiology.
Case Report.
A 19-year old man with no medical history presented to the Emergency Department with a 20-day history of anasarca and frothy urine, BUN 68 mg/dL, Cr 2.3 mg/dL, urinalysis 3+ RBCs, 3+ protein, and urine protein : creatinine ratio 6.4.
Renal biopsy revealed hypertrophic podocytes on light microscopy, podocyte foot process effacement on electron microscopy, and immunofluorescent mesangial staining for IgA.
The patient was started on prednisone and exhibited dramatic improvement.
Discussion.
MCD typically has an overwhelming improvement with glucocorticoids, while the resolution of IgA nephropathy is rare.
Our patient presented with MCD with the uncharacteristic finding of hematuria.
Given the improvement with glucocorticoids, we raise the question of whether there is a shared pathophysiologic component of these two distinct clinical diseases that represents a clinical variant.
American Psychological Association (APA)
Oberweis, Brandon S.& Mattoo, Aditya& Wu, Ming& Goldfarb, David S.. 2013. Minimal Change Disease and IgA Deposition : Separate Entities or Common Pathophysiology?. Case Reports in Nephrology،Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-458912
Modern Language Association (MLA)
Oberweis, Brandon S.…[et al.]. Minimal Change Disease and IgA Deposition : Separate Entities or Common Pathophysiology?. Case Reports in Nephrology No. 2013 (2013), pp.1-3.
https://search.emarefa.net/detail/BIM-458912
American Medical Association (AMA)
Oberweis, Brandon S.& Mattoo, Aditya& Wu, Ming& Goldfarb, David S.. Minimal Change Disease and IgA Deposition : Separate Entities or Common Pathophysiology?. Case Reports in Nephrology. 2013. Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-458912
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458912