Visual Performance in Patients with Neovascular Age-Related Macular Degeneration Undergoing Treatment with Intravitreal Ranibizumab
Joint Authors
Nolan, John M.
Meagher, Katherine A.
Stack, Jim
Sabour-Pickett, Sarah
Beatty, Stephen
Pesudovs, Konrad
Loughman, James
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
To assess visual function and its response to serial intravitreal ranibizumab (Lucentis, Genentech) in patients with neovascular age-related macular degeneration (nv-AMD).
Methods.
Forty-seven eyes of 47 patients with nv-AMD, and corrected distance visual acuity (CDVA) logMAR 0.7 or better, undergoing intravitreal injections of ranibizumab, were enrolled into this prospective study.
Visual function was assessed using a range of psychophysical tests, while mean foveal thickness (MFT) was determined by optical coherence tomography (OCT).
Results.
Group mean (±sd) MFT reduced significantly from baseline (233 (±59)) to exit (205 (±40)) (P=0.001).
CDVA exhibited no change between baseline and exit visits (P=0.48 and P=0.31, resp.).
Measures of visual function that did exhibit statistically significant improvements (P<0.05 for all) included reading acuity, reading speed, mesopic and photopic contrast sensitivity (CS), mesopic and photopic glare disability (GD), and retinotopic ocular sensitivity (ROS) at all eccentricities.
Conclusion.
Eyes with nv-AMD undergoing intravitreal ranibizumab injections exhibit improvements in many parameters of visual function.
Outcome measures other than CDVA, such as CS, GD, and ROS, should not only be considered in the design of studies investigating nv-AMD, but also in treatment and retreatment strategies for patients with the condition.
American Psychological Association (APA)
Sabour-Pickett, Sarah& Loughman, James& Nolan, John M.& Stack, Jim& Meagher, Katherine A.& Beatty, Stephen…[et al.]. 2013. Visual Performance in Patients with Neovascular Age-Related Macular Degeneration Undergoing Treatment with Intravitreal Ranibizumab. Journal of Ophthalmology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-458919
Modern Language Association (MLA)
Meagher, Katherine A.…[et al.]. Visual Performance in Patients with Neovascular Age-Related Macular Degeneration Undergoing Treatment with Intravitreal Ranibizumab. Journal of Ophthalmology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-458919
American Medical Association (AMA)
Sabour-Pickett, Sarah& Loughman, James& Nolan, John M.& Stack, Jim& Meagher, Katherine A.& Beatty, Stephen…[et al.]. Visual Performance in Patients with Neovascular Age-Related Macular Degeneration Undergoing Treatment with Intravitreal Ranibizumab. Journal of Ophthalmology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-458919
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458919