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Assessing Cerebrovascular Reactivity in Carotid Steno-Occlusive Disease Using MRI BOLD and ASL Techniques
Joint Authors
Silva, Afonso C.
Mazzetto-Betti, Kelley C.
dos Santos, Antonio C.
Pontes-Neto, Octavio M.
de Araujo, Draulio B.
Leite, João P.
Leoni, Renata F.
Source
Radiology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Impaired cerebrovascular reactivity (CVR), a predictive factor of imminent stroke, has been shown to be associated with carotid steno-occlusive disease.
Magnetic resonance imaging (MRI) techniques, such as blood oxygenation level-dependent (BOLD) and arterial spin labeling (ASL), have emerged as promising noninvasive tools to evaluate altered CVR with whole-brain coverage, when combined with a vasoactive stimulus, such as respiratory task or injection of acetazolamide.
Under normal cerebrovascular conditions, CVR has been shown to be globally and homogenously distributed between hemispheres, but with differences among cerebral regions.
Such differences can be explained by anatomical specificities and different biochemical mechanisms responsible for vascular regulation.
In patients with carotid steno-occlusive disease, studies have shown that MRI techniques can detect impaired CVR in brain tissue supplied by the affected artery.
Moreover, resulting CVR estimations have been well correlated to those obtained with more established techniques, indicating that BOLD and ASL are robust and reliable methods to assess CVR in patients with cerebrovascular diseases.
Therefore, the present paper aims to review recent studies which use BOLD and ASL to evaluate CVR, in healthy individuals and in patients with carotid steno-occlusive disease, providing a source of information regarding the obtained results and the methodological difficulties.
American Psychological Association (APA)
Leoni, Renata F.& Mazzetto-Betti, Kelley C.& Silva, Afonso C.& dos Santos, Antonio C.& de Araujo, Draulio B.& Leite, João P.…[et al.]. 2012. Assessing Cerebrovascular Reactivity in Carotid Steno-Occlusive Disease Using MRI BOLD and ASL Techniques. Radiology Research and Practice،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-458923
Modern Language Association (MLA)
Leoni, Renata F.…[et al.]. Assessing Cerebrovascular Reactivity in Carotid Steno-Occlusive Disease Using MRI BOLD and ASL Techniques. Radiology Research and Practice No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-458923
American Medical Association (AMA)
Leoni, Renata F.& Mazzetto-Betti, Kelley C.& Silva, Afonso C.& dos Santos, Antonio C.& de Araujo, Draulio B.& Leite, João P.…[et al.]. Assessing Cerebrovascular Reactivity in Carotid Steno-Occlusive Disease Using MRI BOLD and ASL Techniques. Radiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-458923
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458923