Focal Nodular Hyperplasia and Hepatocellular Adenoma around the World Viewed through the Scope of the Immunopathological Classification
Joint Authors
Thung, Swan N.
Huang, Shiu-Feng
Torbenson, Michael
Bioulac-Sage, Paulette
Wee, Aileen
Chen, Pei-Jer
Le Bail, Brigitte
Longerich, Thomas
Hernandez-Prera, Juan C.
al-Rabih, Wesal R.
Balabaud, Charles
Quaglia, Alberto
Evason, Kimberley
Yeh, Shiou-Hwei
Zucman-Rossi, Jessica
Sempoux, Christine
Park, Young Nyun
Ferrell, Linda
Schirmacher, Peter
Yeh, Matthew M.
Source
International Journal of Hepatology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) are benign hepatocellular tumors.
The risk of bleeding and malignant transformation of HCA are strong arguments to differentiate HCA from FNH.
Despite great progress that has been made in the differential radiological diagnosis of the 2 types of nodules, liver biopsy is sometimes necessary to separate the 2 entities.
Identification of HCA subtypes using immunohistochemical techniques, namely, HNF1A-inactivated HCA (35–40%), inflammatory HCA (IHCA), and beta-catenin-mutated inflammatory HCA (b-IHCA) (50–55%), beta-catenin-activated HCA (5–10%), and unclassified HCA (10%) has greatly improved the diagnostic accuracy of benign hepatocellular nodules.
If HCA malignant transformation occurs in all HCA subgroups, the risk is by far the highest in the β-catenin-mutated subgroups (b-HCA, b-IHCA).
In the coming decade the management of HCA will be more dependent on the identification of HCA subtypes, particularly for smaller nodules (<5 cm) in terms of imaging, follow-up, and resection.
American Psychological Association (APA)
Balabaud, Charles& al-Rabih, Wesal R.& Chen, Pei-Jer& Evason, Kimberley& Ferrell, Linda& Hernandez-Prera, Juan C.…[et al.]. 2013. Focal Nodular Hyperplasia and Hepatocellular Adenoma around the World Viewed through the Scope of the Immunopathological Classification. International Journal of Hepatology،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-458939
Modern Language Association (MLA)
Balabaud, Charles…[et al.]. Focal Nodular Hyperplasia and Hepatocellular Adenoma around the World Viewed through the Scope of the Immunopathological Classification. International Journal of Hepatology No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-458939
American Medical Association (AMA)
Balabaud, Charles& al-Rabih, Wesal R.& Chen, Pei-Jer& Evason, Kimberley& Ferrell, Linda& Hernandez-Prera, Juan C.…[et al.]. Focal Nodular Hyperplasia and Hepatocellular Adenoma around the World Viewed through the Scope of the Immunopathological Classification. International Journal of Hepatology. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-458939
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458939