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Extracellular Matrix Proteins Modulate Antimigratory and Apoptotic Effects of Doxorubicin
Joint Authors
Guilbert, Marie
El Btaouri, Hassan
Garnotel, Roselyne
Morjani, Hamid
Said, Georges
Jeannesson, Pierre
Source
Chemotherapy Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Anticancer drug resistance is a multifactorial process that includes acquired and de novo drug resistances.
Acquired resistance develops during treatment, while de novo resistance is the primary way for tumor cells to escape chemotherapy.
Tumor microenvironment has been recently shown to be one of the important factors contributing to de novo resistance and called environment-mediated drug resistance (EMDR).
Two forms of EMDR have been described: soluble factor-mediated drug resistance (SFM-DR) and cell adhesion-mediated drug resistance (CAM-DR).
Anthracyclines, among the most potent chemotherapeutic agents, are widely used in clinics against hematopoietic and solid tumors.
Their main mechanism of action relies on the inhibition of topoisomerase I and/or II and the induction of apoptosis.
Beyond this well-known antitumor activity, it has been recently demonstrated that anthracyclines may display potent anti-invasive effects when used at subtoxic concentrations.
In this paper, we will describe two particular modes of EMDR by which microenvironment may influence tumor-cell response to one of these anthracyclines, doxorubicin.
The first one considers the influence of type I collagen on the antimigratory effect of doxorubicin (CAM-DR).
The second considers the protection of tumor cells by thrombospondin-I against doxorubicin-induced apoptosis (SFM-DR).
American Psychological Association (APA)
Said, Georges& Guilbert, Marie& Morjani, Hamid& Garnotel, Roselyne& Jeannesson, Pierre& El Btaouri, Hassan. 2012. Extracellular Matrix Proteins Modulate Antimigratory and Apoptotic Effects of Doxorubicin. Chemotherapy Research and Practice،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-458947
Modern Language Association (MLA)
Said, Georges…[et al.]. Extracellular Matrix Proteins Modulate Antimigratory and Apoptotic Effects of Doxorubicin. Chemotherapy Research and Practice No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-458947
American Medical Association (AMA)
Said, Georges& Guilbert, Marie& Morjani, Hamid& Garnotel, Roselyne& Jeannesson, Pierre& El Btaouri, Hassan. Extracellular Matrix Proteins Modulate Antimigratory and Apoptotic Effects of Doxorubicin. Chemotherapy Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-458947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458947