Systems Biology : The Next Frontier for Bioinformatics
Joint Authors
Bacic, Antony
McConville, Malcolm J.
Lithgow, Trevor
Likić, Vladimir A.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Biochemical systems biology augments more traditional disciplines, such as genomics, biochemistry and molecular biology, by championing (i) mathematical and computational modeling; (ii) the application of traditional engineering practices in the analysis of biochemical systems; and in the past decade increasingly (iii) the use of near-comprehensive data sets derived from ‘omics platform technologies, in particular “downstream” technologies relative to genome sequencing, including transcriptomics, proteomics and metabolomics.
The future progress in understanding biological principles will increasingly depend on the development of temporal and spatial analytical techniques that will provide high-resolution data for systems analyses.
To date, particularly successful were strategies involving (a) quantitative measurements of cellular components at the mRNA, protein and metabolite levels, as well as in vivo metabolic reaction rates, (b) development of mathematical models that integrate biochemical knowledge with the information generated by high-throughput experiments, and (c) applications to microbial organisms.
The inevitable role bioinformatics plays in modern systems biology puts mathematical and computational sciences as an equal partner to analytical and experimental biology.
Furthermore, mathematical and computational models are expected to become increasingly prevalent representations of our knowledge about specific biochemical systems.
American Psychological Association (APA)
Likić, Vladimir A.& McConville, Malcolm J.& Lithgow, Trevor& Bacic, Antony. 2011. Systems Biology : The Next Frontier for Bioinformatics. Advances in Bioinformatics،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-458964
Modern Language Association (MLA)
Likić, Vladimir A.…[et al.]. Systems Biology : The Next Frontier for Bioinformatics. Advances in Bioinformatics No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-458964
American Medical Association (AMA)
Likić, Vladimir A.& McConville, Malcolm J.& Lithgow, Trevor& Bacic, Antony. Systems Biology : The Next Frontier for Bioinformatics. Advances in Bioinformatics. 2011. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-458964
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458964