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Sequence Analysis of the UCP1 Gene in a Severe Obese Population from Southern Italy
Joint Authors
Sacchetti, Lucia
Fortunato, Giuliana
Nardelli, Carmela
Contaldo, Franco
Labruna, Giuseppe
Finelli, Carmine
Farinaro, Eduardo
Pasanisi, Fabrizio
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Brown adipose tissue, where Uncoupling Protein 1 (UCP1) activity uncouples mitochondrial respiration, is an important site of facultative energy expenditure.
This tissue may normally function to prevent obesity.
Our aim was to investigate by sequence analysis the presence of UCP1 gene variations that may be associated with obesity.
We studied 100 severe obese adults (BMI > 40 kg/m2) and 100 normal-weight control subjects (BMI range = 19–24.9 kg/m2).
We identified 7 variations in the promoter region, 4 in the intronic region and 4 in the exonic region.
Globally, 72% of obese patients bore UCP1 polymorphisms.
Among UCP1 variants, g.IVS4−208T>G SNP was associated with obesity (OR: 1.77; 95% CI = 1.26–2.50; P=.001).
Further, obese patients bearing the g.−451C>T (CT+TT) or the g.940G>A (GA+AA) genotypes showed a higher BMI than not polymorphic obese patients (P=.008 and P=.043, resp.).
In conclusion, UCP1 SNPs could represent “thrifty” factors that promote energy storage in prone subjects.
American Psychological Association (APA)
Labruna, Giuseppe& Pasanisi, Fabrizio& Fortunato, Giuliana& Nardelli, Carmela& Finelli, Carmine& Farinaro, Eduardo…[et al.]. 2011. Sequence Analysis of the UCP1 Gene in a Severe Obese Population from Southern Italy. Journal of Obesity،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-458977
Modern Language Association (MLA)
Labruna, Giuseppe…[et al.]. Sequence Analysis of the UCP1 Gene in a Severe Obese Population from Southern Italy. Journal of Obesity No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-458977
American Medical Association (AMA)
Labruna, Giuseppe& Pasanisi, Fabrizio& Fortunato, Giuliana& Nardelli, Carmela& Finelli, Carmine& Farinaro, Eduardo…[et al.]. Sequence Analysis of the UCP1 Gene in a Severe Obese Population from Southern Italy. Journal of Obesity. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-458977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458977