The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia : Beyond PTH Control
Joint Authors
Brenna, Irene
Stucchi, Andrea
Volpi, Elisa
Mehmeti, Florjan
Cusi, Daniele
Cozzolino, Mario
Ciceri, Paola
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Secondary hyperparathyroidism is a systemic disorder that associates with bone and cardiovascular disease, including arterial calcification.
Treatment with calcitriol, the active form of vitamin D, reduces parathyroid hormone levels, but may result in elevations in serum calcium and phosphorus, increasing the risk of vascular calcification in dialysis patients.
New vitamin D receptor activators (VDRAs) have been developed and investigated with the rationale to treat high serum PTH levels, with a reduced risk of hypercalcemia and hyperphosphatemia.
Paricalcitol is a selective VDRA that suppresses PTH secretion with minimal increases on serum calcium and phosphate.
Moreover, paricalcitol prevents vascular calcification in experimental models of renal failure, compared with calcitriol.
American Psychological Association (APA)
Cozzolino, Mario& Mehmeti, Florjan& Ciceri, Paola& Volpi, Elisa& Stucchi, Andrea& Brenna, Irene…[et al.]. 2011. The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia : Beyond PTH Control. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-458979
Modern Language Association (MLA)
Cozzolino, Mario…[et al.]. The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia : Beyond PTH Control. International Journal of Nephrology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-458979
American Medical Association (AMA)
Cozzolino, Mario& Mehmeti, Florjan& Ciceri, Paola& Volpi, Elisa& Stucchi, Andrea& Brenna, Irene…[et al.]. The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia : Beyond PTH Control. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-458979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458979