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Object-Place Recognition Learning Triggers Rapid Induction of Plasticity-Related Immediate Early Genes and Synaptic Proteins in the Rat Dentate Gyrus
Joint Authors
Bramham, Clive R.
Laroche, Serge
Soulé, Jonathan
Penke, Zsuzsa
Kanhema, Tambudzai
Alme, Maria Nordheim
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-01-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Long-term recognition memory requires protein synthesis, but little is known about the coordinate regulation of specific genes.
Here, we examined expression of the plasticity-associated immediate early genes (Arc, Zif268, and Narp) in the dentate gyrus following long-term object-place recognition learning in rats.
RT-PCR analysis from dentate gyrus tissue collected shortly after training did not reveal learning-specific changes in Arc mRNA expression.
In situ hybridization and immunohistochemistry were therefore used to assess possible sparse effects on gene expression.
Learning about objects increased the density of granule cells expressing Arc, and to a lesser extent Narp, specifically in the dorsal blade of the dentate gyrus, while Zif268 expression was elevated across both blades.
Thus, object-place recognition triggers rapid, blade-specific upregulation of plasticity-associated immediate early genes.
Furthermore, Western blot analysis of dentate gyrus homogenates demonstrated concomitant upregulation of three postsynaptic density proteins (Arc, PSD-95, and α-CaMKII) with key roles in long-term synaptic plasticity and long-term memory.
American Psychological Association (APA)
Soulé, Jonathan& Penke, Zsuzsa& Kanhema, Tambudzai& Alme, Maria Nordheim& Laroche, Serge& Bramham, Clive R.. 2009. Object-Place Recognition Learning Triggers Rapid Induction of Plasticity-Related Immediate Early Genes and Synaptic Proteins in the Rat Dentate Gyrus. Neural Plasticity،Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-458982
Modern Language Association (MLA)
Soulé, Jonathan…[et al.]. Object-Place Recognition Learning Triggers Rapid Induction of Plasticity-Related Immediate Early Genes and Synaptic Proteins in the Rat Dentate Gyrus. Neural Plasticity No. 2008 (2008), pp.1-12.
https://search.emarefa.net/detail/BIM-458982
American Medical Association (AMA)
Soulé, Jonathan& Penke, Zsuzsa& Kanhema, Tambudzai& Alme, Maria Nordheim& Laroche, Serge& Bramham, Clive R.. Object-Place Recognition Learning Triggers Rapid Induction of Plasticity-Related Immediate Early Genes and Synaptic Proteins in the Rat Dentate Gyrus. Neural Plasticity. 2009. Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-458982
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458982