The Role of miRNA in Haematological Malignancy
Joint Authors
Gounaris-Shannon, Stephanie
Chevassut, Timothy J.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Currently, there are over 1,800 annotated human miRNAs, many of which have tissue-specific expression.
Numerous studies have highlighted their role in haematopoietic differentiation and proliferation, acting as master regulators of haematopoietic stem cell function.
Aberrant expression of miRNAs has been observed in haematological cancers, exhibiting unique expression signatures in comparison to normal counterparts.
Functional and target analyses as well as animal models have attempted to annotate how different miRNA may contribute to the pathophysiology of these malignancies from modulating cancer associated genes, functioning directly as oncogenes or tumour suppressor genes or acting as bystanders or regulators of the epigenetic mechanisms in cancer.
miRNAs have also been shown to play a role in modulating drug resistance and determining prognosis between the various subtypes of blood cancers.
This review discusses the important role that miRNAs play in haematological malignancies by exploring associations that exist between the two and trying to examine evidence of causality to support the tantalising possibility that miRNAs might serve as therapeutic targets in blood cancers.
American Psychological Association (APA)
Gounaris-Shannon, Stephanie& Chevassut, Timothy J.. 2013. The Role of miRNA in Haematological Malignancy. Bone Marrow Research،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-458983
Modern Language Association (MLA)
Gounaris-Shannon, Stephanie& Chevassut, Timothy J.. The Role of miRNA in Haematological Malignancy. Bone Marrow Research No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-458983
American Medical Association (AMA)
Gounaris-Shannon, Stephanie& Chevassut, Timothy J.. The Role of miRNA in Haematological Malignancy. Bone Marrow Research. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-458983
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458983