Effect of Equal Daily Doses Achieved by Different Power Densities of Low-Level Laser Therapy at 635 nm on Open Skin Wound Healing in Normal and Diabetic Rats
Joint Authors
Longauer, František
Kilík, Róbert
Vidová, Martina
Kruzliak, Peter
Radoňak, Jozef
Lakyová, Lucia
Sabo, Ján
Vasilenko, Tomáš
Lacjaková, Kamila
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background and Objective.
Despite the fact that the molecular mechanism of low-level laser therapy (LLLT) is not yet known, the exploitation of phototherapy in clinical medicine and surgery is of great interest.
The present study investigates the effects of LLLT on open skin wound healing in normal and diabetic rats.
Materials and Methods.
Four round full-thickness skin wounds on dorsum were performed in male adult nondiabetic (n=24) and diabetic (n=24) Sprague–Dawley rats.
AlGaInP (635 nm, wavelength; 5 J/cm2, daily dose) was used to deliver power densities of 1, 5, and 15 mW/cm2 three times daily until euthanasia.
Results.
PMNL infiltration was lower in the irradiated groups (15 mW/cm2).
The synthesis and organisation of collagen fibres were consecutively enhanced in the 5 mW/cm2 and 15 mW/cm2 groups compared to the others in nondiabetic rats.
In the diabetic group the only significant difference was recorded in the ratio PMNL/Ma at 15 mW/cm2.
A significant difference in the number of newly formed capillaries in the irradiated group (5, 15 mW/cm2) was recorded on day six after injury compared to the control group.
Conclusion.
LLLT confers a protective effect against excessive inflammatory tissue response; it stimulates neovascularization and the early formation of collagen fibres.
American Psychological Association (APA)
Kilík, Róbert& Lakyová, Lucia& Sabo, Ján& Kruzliak, Peter& Lacjaková, Kamila& Vasilenko, Tomáš…[et al.]. 2014. Effect of Equal Daily Doses Achieved by Different Power Densities of Low-Level Laser Therapy at 635 nm on Open Skin Wound Healing in Normal and Diabetic Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-458996
Modern Language Association (MLA)
Kilík, Róbert…[et al.]. Effect of Equal Daily Doses Achieved by Different Power Densities of Low-Level Laser Therapy at 635 nm on Open Skin Wound Healing in Normal and Diabetic Rats. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-458996
American Medical Association (AMA)
Kilík, Róbert& Lakyová, Lucia& Sabo, Ján& Kruzliak, Peter& Lacjaková, Kamila& Vasilenko, Tomáš…[et al.]. Effect of Equal Daily Doses Achieved by Different Power Densities of Low-Level Laser Therapy at 635 nm on Open Skin Wound Healing in Normal and Diabetic Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-458996
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458996