Effect of Equal Daily Doses Achieved by Different Power Densities of Low-Level Laser Therapy at 635 nm on Open Skin Wound Healing in Normal and Diabetic Rats

Joint Authors

Longauer, František
Kilík, Róbert
Vidová, Martina
Kruzliak, Peter
Radoňak, Jozef
Lakyová, Lucia
Sabo, Ján
Vasilenko, Tomáš
Lacjaková, Kamila

Source

BioMed Research International

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-01-16

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Medicine

Abstract EN

Background and Objective.

Despite the fact that the molecular mechanism of low-level laser therapy (LLLT) is not yet known, the exploitation of phototherapy in clinical medicine and surgery is of great interest.

The present study investigates the effects of LLLT on open skin wound healing in normal and diabetic rats.

Materials and Methods.

Four round full-thickness skin wounds on dorsum were performed in male adult nondiabetic (n=24) and diabetic (n=24) Sprague–Dawley rats.

AlGaInP (635 nm, wavelength; 5 J/cm2, daily dose) was used to deliver power densities of 1, 5, and 15 mW/cm2 three times daily until euthanasia.

Results.

PMNL infiltration was lower in the irradiated groups (15 mW/cm2).

The synthesis and organisation of collagen fibres were consecutively enhanced in the 5 mW/cm2 and 15 mW/cm2 groups compared to the others in nondiabetic rats.

In the diabetic group the only significant difference was recorded in the ratio PMNL/Ma at 15 mW/cm2.

A significant difference in the number of newly formed capillaries in the irradiated group (5, 15 mW/cm2) was recorded on day six after injury compared to the control group.

Conclusion.

LLLT confers a protective effect against excessive inflammatory tissue response; it stimulates neovascularization and the early formation of collagen fibres.

American Psychological Association (APA)

Kilík, Róbert& Lakyová, Lucia& Sabo, Ján& Kruzliak, Peter& Lacjaková, Kamila& Vasilenko, Tomáš…[et al.]. 2014. Effect of Equal Daily Doses Achieved by Different Power Densities of Low-Level Laser Therapy at 635 nm on Open Skin Wound Healing in Normal and Diabetic Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-458996

Modern Language Association (MLA)

Kilík, Róbert…[et al.]. Effect of Equal Daily Doses Achieved by Different Power Densities of Low-Level Laser Therapy at 635 nm on Open Skin Wound Healing in Normal and Diabetic Rats. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-458996

American Medical Association (AMA)

Kilík, Róbert& Lakyová, Lucia& Sabo, Ján& Kruzliak, Peter& Lacjaková, Kamila& Vasilenko, Tomáš…[et al.]. Effect of Equal Daily Doses Achieved by Different Power Densities of Low-Level Laser Therapy at 635 nm on Open Skin Wound Healing in Normal and Diabetic Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-458996

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-458996