Immune Recovery after Cyclophosphamide Treatment in Multiple Myeloma : Implication for Maintenance Immunotherapy
Joint Authors
Haran-Ghera, Nechama
Sharabi, Amir
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Multiple myeloma (MM) is a progressive B-lineage neoplasia characterized by clonal proliferation of malignant plasma cells.
Increased numbers of regulatory T cells (Tregs) were determined in mouse models and in patients with MM, which correlated with disease burden.
Thus, it became rational to target Tregs for treating MM.
The effects of common chemotherapeutic drugs on Tregs are reviewed with a focus on cyclophosphamide (CYC).
Studies indicated that selective depletion of Tregs may be accomplished following the administration of a low-dose CYC.
We report that continuous nonfrequent administrations of CYC at low doses block the renewal of Tregs in MM-affected mice and enable the restoration of an efficient immune response against the tumor cells, thereby leading to prolonged survival and prevention of disease recurrence.
Hence, distinctive time-schedule injections of low-dose CYC are beneficial for breaking immune tolerance against MM tumor cells.
American Psychological Association (APA)
Sharabi, Amir& Haran-Ghera, Nechama. 2011. Immune Recovery after Cyclophosphamide Treatment in Multiple Myeloma : Implication for Maintenance Immunotherapy. Bone Marrow Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-459031
Modern Language Association (MLA)
Sharabi, Amir& Haran-Ghera, Nechama. Immune Recovery after Cyclophosphamide Treatment in Multiple Myeloma : Implication for Maintenance Immunotherapy. Bone Marrow Research No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-459031
American Medical Association (AMA)
Sharabi, Amir& Haran-Ghera, Nechama. Immune Recovery after Cyclophosphamide Treatment in Multiple Myeloma : Implication for Maintenance Immunotherapy. Bone Marrow Research. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-459031
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459031