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Antibacterial Effect of Autologous Platelet-Rich Gel Derived from Subjects with Diabetic Dermal Ulcers In Vitro
Joint Authors
Liu, Guanjian
Wang, Chun
Chen, Lihong
Ran, Xingwu
Liu, Hengchuan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Autologous platelet-rich gel (APG) is an effective method to improve ulcer healing.
However, the mechanisms are not clear.
This study aimed to investigate the antibacterial effect of APG in vitro.
Methods.
Platelet-rich plasma (PRP), platelet-poor plasma (PPP) and APG were prepared from whole blood of sixteen diabetic patients with dermal ulcers.
Antibacterial effects against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa were evaluated by bacteriostasis assay of APG, PRP, and APG-APO (APG combined with apocynin), with phosphate-buffered saline (PBS) and PPP as the control group.
Results.
(1) Compared to the PBS and PPP, the APG and APG-APO groups showed strong antibacterial activity against Staphylococcus aureus.
There was no significant difference (P>0.05) between APG and APG-APO.
(2) Compared to PBS, APG, APG-APO, and PRP showed obvious antibacterial effects against Escherichia coli and Pseudomonas aeruginosa.
No significant difference (P>0.05) was revealed among the three groups.
Compared to the PPP group, they did not show antibacterial effect against Escherichia coli and Pseudomonas aeruginosa (P>0.05).
Conclusions.
APG has antibacterial effect against Staphylococcus aureus mediated by platelet activation in the diabetic patients with dermal ulcer, and does not present obvious antibacterial effect against Escherichia coli or Pseudomonas aeruginosa.
Combination of APG and antibiotics may have synergistic antibacterial effect.
American Psychological Association (APA)
Chen, Lihong& Wang, Chun& Liu, Hengchuan& Liu, Guanjian& Ran, Xingwu. 2013. Antibacterial Effect of Autologous Platelet-Rich Gel Derived from Subjects with Diabetic Dermal Ulcers In Vitro. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-459034
Modern Language Association (MLA)
Chen, Lihong…[et al.]. Antibacterial Effect of Autologous Platelet-Rich Gel Derived from Subjects with Diabetic Dermal Ulcers In Vitro. Journal of Diabetes Research No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-459034
American Medical Association (AMA)
Chen, Lihong& Wang, Chun& Liu, Hengchuan& Liu, Guanjian& Ran, Xingwu. Antibacterial Effect of Autologous Platelet-Rich Gel Derived from Subjects with Diabetic Dermal Ulcers In Vitro. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-459034
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459034