Relationship between Plasma Leptin Level and Chronic Kidney Disease
Joint Authors
Muntner, Paul
Xiao, Jie
Syamala, Shirmila
Shankar, Anoop
Source
International Journal of Nephrology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Leptin is an adipose tissue-derived hormone shown to be related to several metabolic, inflammatory, and hemostatic factors related to chronic kidney disease.
Recent animal studies have reported that infusion of recombinant leptin into normal rats for 3 weeks fosters the development of glomerulosclerosis.
However, few studies have examined the association between leptin and CKD in humans.
Therefore, we examined the association between plasma leptin levels and CKD in a representative sample of US adults.
Methods.
We examined the third National Health and Nutrition Examination Survey participants >20 years of age (n=5820, 53.6% women).
Plasma leptin levels were categorized into quartiles (≤4.3 Fg/L, 4.4–8.7 Fg/L, 8.8–16.9 Fg/L, >16.9 Fg/L).
CKD was defined as a glomerular filtration rate of <60 mL/min/1.73 m2 estimated from serum creatinine.
Results.
Higher plasma leptin levels were associated with CKD after adjusting for age, sex, race/ethnicity, education, smoking, alcohol intake, body mass index (BMI), diabetes, hypertension, and serum cholesterol.
Compared to quartile 1 of leptin (referent), the odds ratio (95% confidence interval) of CKD associated with quartile 4 was 3.31 (1.41 to 7.78); P-trend = 0.0135.
Subgroup analyses examining the relation between leptin and CKD by gender, BMI categories, diabetes, and hypertension status also showed a consistent positive association.
Conclusion.
Higher plasma leptin levels are associated with CKD in a representative sample of US adults.
American Psychological Association (APA)
Shankar, Anoop& Syamala, Shirmila& Xiao, Jie& Muntner, Paul. 2012. Relationship between Plasma Leptin Level and Chronic Kidney Disease. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-459036
Modern Language Association (MLA)
Shankar, Anoop…[et al.]. Relationship between Plasma Leptin Level and Chronic Kidney Disease. International Journal of Nephrology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-459036
American Medical Association (AMA)
Shankar, Anoop& Syamala, Shirmila& Xiao, Jie& Muntner, Paul. Relationship between Plasma Leptin Level and Chronic Kidney Disease. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-459036
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459036