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The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic Dermatitis
Joint Authors
Zakrzewski, Marcin
Stelmach, Iwona
Bogaczewicz, Jarosław
Kuna, Piotr
Narbutt, Joanna
Lesiak, Aleksandra
Anna, Sysa-Jedrzejowska
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-07-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Atopic dermatitis (AD) is an inflammatory skin disease in which pathogenesis chemokines are partially involved.
The aim of the paper was to assess the serum level of CXCL-9, CXCL-10, CXCL-11, CXCL-12, CCL-17, CCL-20, CCL-21, CCL-22, CCL-27, and IL-18 chosen in AD patients by ELISA assay.
Forty patients (mean age 11.4 years old) with AD and 50 healthy controls were enrolled into the study.
The patients and controls were divided into two age categories: under 10 years old (Group 1 and Control 1) and over 10 years old (Group 2 and Control 2).
Significantly lower serum concentration of CXCL-9, CXCL-10, CCL-17, and IL-18 and higher concentration of CXCL-12 and CCL-27 were found in Group 1 when compared to Control 1.
In Group 2 serum concentration of CXCL-12, CCL-17, CCL-22 was higher than in Control 2.
The obtained results indicate the imbalance in chemokine serum levels in AD what suggests their role in the disease pathogenesis.
American Psychological Association (APA)
Narbutt, Joanna& Lesiak, Aleksandra& Anna, Sysa-Jedrzejowska& Zakrzewski, Marcin& Bogaczewicz, Jarosław& Stelmach, Iwona…[et al.]. 2009. The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic Dermatitis. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-459038
Modern Language Association (MLA)
Narbutt, Joanna…[et al.]. The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic Dermatitis. Mediators of Inflammation No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-459038
American Medical Association (AMA)
Narbutt, Joanna& Lesiak, Aleksandra& Anna, Sysa-Jedrzejowska& Zakrzewski, Marcin& Bogaczewicz, Jarosław& Stelmach, Iwona…[et al.]. The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic Dermatitis. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-459038
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459038