Splicing Programs and Cancer
Joint Authors
Gratadou, Lise
Auboeuf, Didier
Dutertre, Martin
Germann, Sophie
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Numerous studies report splicing alterations in a multitude of cancers by using gene-by-gene analysis.
However, understanding of the role of alternative splicing in cancer is now reaching a new level, thanks to the use of novel technologies allowing the analysis of splicing at a large-scale level.
Genome-wide analyses of alternative splicing indicate that splicing alterations can affect the products of gene networks involved in key cellular programs.
In addition, many splicing variants identified as being misregulated in cancer are expressed in normal tissues.
These observations suggest that splicing programs contribute to specific cellular programs that are altered during cancer initiation and progression.
Supporting this model, recent studies have identified splicing factors controlling cancer-associated splicing programs.
The characterization of splicing programs and their regulation by splicing factors will allow a better understanding of the genetic mechanisms involved in cancer initiation and progression and the development of new therapeutic targets.
American Psychological Association (APA)
Germann, Sophie& Gratadou, Lise& Dutertre, Martin& Auboeuf, Didier. 2011. Splicing Programs and Cancer. Journal of Nucleic Acids،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-459041
Modern Language Association (MLA)
Germann, Sophie…[et al.]. Splicing Programs and Cancer. Journal of Nucleic Acids No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-459041
American Medical Association (AMA)
Germann, Sophie& Gratadou, Lise& Dutertre, Martin& Auboeuf, Didier. Splicing Programs and Cancer. Journal of Nucleic Acids. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-459041
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459041