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Coinhibitory Molecules in Autoimmune Diseases
Joint Authors
Nakajima, Hiroshi
Watanabe, Norihiko
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Coinhibitory molecules such as CTLA-4, PD-1 and BTLA negatively regulate immune responses.
Multiple studies indicate that the deficiency or mutation of coinhibitory molecules leads to the development of autoimmune diseases in mice and humans, indicating that the negative signals from coinhibitory molecules are crucial for the prevention of autoimmunity.
In some conditions, the administration of decoy coinhibitory receptors (e.g., CTLA-4 Ig) or mAb against coinhibitory molecules suppresses the responses of self-reactive T cells in autoimmune diseases.
Therefore, modulation of coinhibitory signals seems to be an attractive approach to induce tolerance in autoimmune diseases in humans where the disease-inducing self-antigens are not known.
Particularly, administration of CTLA-4 Ig has shown great promise in animal models of autoimmune diseases and has been gaining increasing attention in clinical investigation in several autoimmune diseases in humans.
American Psychological Association (APA)
Watanabe, Norihiko& Nakajima, Hiroshi. 2012. Coinhibitory Molecules in Autoimmune Diseases. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-459061
Modern Language Association (MLA)
Watanabe, Norihiko& Nakajima, Hiroshi. Coinhibitory Molecules in Autoimmune Diseases. Clinical and Developmental Immunology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-459061
American Medical Association (AMA)
Watanabe, Norihiko& Nakajima, Hiroshi. Coinhibitory Molecules in Autoimmune Diseases. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-459061
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459061