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Ethanol Extract of Ulmus pumila Root Bark Inhibits Clinically Isolated Antibiotic-Resistant Bacteria
Joint Authors
You, Yong-Ouk
Kim, Kang-Ju
Choi, Na-Young
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In this study, root bark of Ulmus pumila (U.
pumila) was extracted with ethanol, and then the antimicrobial effects were tested on clinically isolated 12 MRSA strains and 1 standard MRSA strain.
U.
pumila showed antibacterial activities against all MRSA strains.
Minimum inhibitory concentration (MIC) of U.
pumila root bark against all MRSA strains revealed a range from 125 to 250 μg/mL.
These results may provide the scientific basis on which U.
pumila root bark has traditionally been used against infectious diseases in Korea.
In real-time PCR analysis, the sub-MIC (64–125 μg/mL) concentrations of U.
pumila root bark extract showed the inhibition of the genetic expressions of virulence factors such as mecA, sea, agrA, and sarA in standard MRSA.
Phytochemical analyses of U.
pumila root bark showed relatively strong presence of phenolics, steroids, and terpenoids.
These results suggest that the ethanol extract of U.
pumila root bark may have antibacterial activity against MRSA, which may be related to the phytochemicals such as phenolics, steroids, and terpenoids.
Further studies are needed to determine the active constituents of U.
pumila root bark responsible for such biomolecular activities.
American Psychological Association (APA)
You, Yong-Ouk& Choi, Na-Young& Kim, Kang-Ju. 2013. Ethanol Extract of Ulmus pumila Root Bark Inhibits Clinically Isolated Antibiotic-Resistant Bacteria. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-459067
Modern Language Association (MLA)
You, Yong-Ouk…[et al.]. Ethanol Extract of Ulmus pumila Root Bark Inhibits Clinically Isolated Antibiotic-Resistant Bacteria. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-459067
American Medical Association (AMA)
You, Yong-Ouk& Choi, Na-Young& Kim, Kang-Ju. Ethanol Extract of Ulmus pumila Root Bark Inhibits Clinically Isolated Antibiotic-Resistant Bacteria. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-459067
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459067