Clinical Utility of Serum Interleukin-8 and Interferon-Alpha in Thyroid Diseases
Joint Authors
Patel, Kamini N.
Kobawala, Toral P.
Gajjar, Dhara R.
Shah, Pankaj M.
Shukla, Shilin N.
Parekh, Urvi B.
Patel, Kirti M.
Thakor, Premal B.
Patel, Girish H.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Serum interleukin-8 (IL-8) and interferon-alpha (IFN-α) levels have been estimated from a total of 88 individuals of which 19 were disease-free healthy individuals, and 69 were patients with thyroid diseases: goitre (N=21), autoimmune diseases (N=16), and carcinomas (N=32).
Both IL-8 and IFN-α were significantly higher in all the patients as compared to healthy individuals.
Serum IL-8 levels showed significant positive correlation with disease stage in thyroid cancer patients.
Higher serum IL-8 levels were associated with advanced disease stage while no significant correlation was observed between serum IFN-α levels and any of the clinicopathological parameters.
IL-8 and IFN-α significantly correlated with each other in anaplastic carcinoma patients.
Finally concluding, monitoring the serum IL-8 and IFN-α levels can help differentiate patients with thyroid diseases from healthy individuals, and IL-8 seems to have a role in the pathogenesis of thyroid diseases and may represent a target for innovative diagnostic and therapeutic strategies.
American Psychological Association (APA)
Kobawala, Toral P.& Patel, Girish H.& Gajjar, Dhara R.& Patel, Kamini N.& Thakor, Premal B.& Parekh, Urvi B.…[et al.]. 2011. Clinical Utility of Serum Interleukin-8 and Interferon-Alpha in Thyroid Diseases. Journal of Thyroid Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-459073
Modern Language Association (MLA)
Kobawala, Toral P.…[et al.]. Clinical Utility of Serum Interleukin-8 and Interferon-Alpha in Thyroid Diseases. Journal of Thyroid Research No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-459073
American Medical Association (AMA)
Kobawala, Toral P.& Patel, Girish H.& Gajjar, Dhara R.& Patel, Kamini N.& Thakor, Premal B.& Parekh, Urvi B.…[et al.]. Clinical Utility of Serum Interleukin-8 and Interferon-Alpha in Thyroid Diseases. Journal of Thyroid Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-459073
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459073