A Case Report and Genetic Characterization of a Massive Acinic Cell Carcinoma of the Parotid with Delayed Distant Metastases
Joint Authors
Lambin, Philippe
Dowthwaite, Samuel A.
Starmans, Maud H. W.
Waggott, Daryl
Mymryk, Joe S.
Winquist, Eric
Barrett, John W.
MacNeil, S. Danielle
Nichols, Anthony C.
Wehrli, Bret
Yoo, John
Boutros, Paul C.
Agrawal, Sumit K.
Fung, Kevin
Koropatnick, James
Harding, Nicholas J.
Chan-Seng-Yue, Michelle
Palma, David A.
Source
Case Reports in Oncological Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We describe the presentation, management, and clinical outcome of a massive acinic cell carcinoma of the parotid gland.
The primary tumor and blood underwent exome sequencing which revealed deletions in CDKN2A as well as PPP1R13B, which induces p53.
A damaging nonsynonymous mutation was noted in EP300, a histone acetylase which plays a role in cellular proliferation.
This study provides the first insights into the genetic underpinnings of this cancer.
Future large-scale efforts will be necessary to define the mutational landscape of salivary gland malignancies to identify therapeutic targets and biomarkers of treatment failure.
American Psychological Association (APA)
Nichols, Anthony C.& Chan-Seng-Yue, Michelle& Yoo, John& Agrawal, Sumit K.& Starmans, Maud H. W.& Waggott, Daryl…[et al.]. 2013. A Case Report and Genetic Characterization of a Massive Acinic Cell Carcinoma of the Parotid with Delayed Distant Metastases. Case Reports in Oncological Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-459085
Modern Language Association (MLA)
Nichols, Anthony C.…[et al.]. A Case Report and Genetic Characterization of a Massive Acinic Cell Carcinoma of the Parotid with Delayed Distant Metastases. Case Reports in Oncological Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-459085
American Medical Association (AMA)
Nichols, Anthony C.& Chan-Seng-Yue, Michelle& Yoo, John& Agrawal, Sumit K.& Starmans, Maud H. W.& Waggott, Daryl…[et al.]. A Case Report and Genetic Characterization of a Massive Acinic Cell Carcinoma of the Parotid with Delayed Distant Metastases. Case Reports in Oncological Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-459085
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459085
