Correlation of Oxidative Stress with Serum Trace Element Levels and Antioxidant Enzyme Status in Beta Thalassemia Major Patients : A Review of the Literature
Joint Authors
Mohammad, Z. H.
Shazia, Q.
Shekhar, Hossain Uddin
Rahman, Taibur
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Beta thalassemia major is an inherited disease resulting from reduction or total lack of beta globin chains.
Patients with this disease need repeated blood transfusion for survival.
This may cause oxidative stress and tissue injury due to iron overload, altered antioxidant enzymes, and other essential trace element levels.
The aim of this review is to scrutinize the relationship between oxidative stress and serum trace elements, degree of damage caused by oxidative stress, and the role of antioxidant enzymes in beta thalassemia major patients.
The findings indicate that oxidative stress in patients with beta thalassemia major is mainly caused by tissue injury due to over production of free radical by secondary iron overload, alteration in serum trace elements and antioxidant enzymes level.
The role of trace elements like selenium, copper, iron, and zinc in beta thalassemia major patients reveals a significant change of these trace elements.
Studies published on the status of antioxidant enzymes like catalase, superoxide dismutase, glutathione, and glutathione S-transferase in beta thalassemia patients also showed variable results.
The administration of selective antioxidants along with essential trace elements and minerals to reduce the extent of oxidative damage and related complications in beta thalassemia major still need further evaluation.
American Psychological Association (APA)
Shazia, Q.& Mohammad, Z. H.& Rahman, Taibur& Shekhar, Hossain Uddin. 2012. Correlation of Oxidative Stress with Serum Trace Element Levels and Antioxidant Enzyme Status in Beta Thalassemia Major Patients : A Review of the Literature. Anemia،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-459155
Modern Language Association (MLA)
Shazia, Q.…[et al.]. Correlation of Oxidative Stress with Serum Trace Element Levels and Antioxidant Enzyme Status in Beta Thalassemia Major Patients : A Review of the Literature. Anemia No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-459155
American Medical Association (AMA)
Shazia, Q.& Mohammad, Z. H.& Rahman, Taibur& Shekhar, Hossain Uddin. Correlation of Oxidative Stress with Serum Trace Element Levels and Antioxidant Enzyme Status in Beta Thalassemia Major Patients : A Review of the Literature. Anemia. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-459155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459155