AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia
Joint Authors
Real, J. T.
Ascaso, J. F.
van den Berg, T. M.
Rietveld, A. P.
Cabezas, Manuel Castro
Chaves, J.
Elte, J. W. F.
Klop, Boudewijn
Carmena, R.
Source
International Journal of Vascular Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Recent data suggest that the renin-angiotensin system may be involved in triglyceride (TG) metabolism.
We explored the effect of the common A1166C and C573T polymorphisms of the angiotensin II type 1 receptor (AT1R) gene on postprandial lipemia.
Methods.
Eighty-two subjects measured daytime capillary TG, and postprandial lipemia was estimated as incremental area under the TG curve.
The C573T and A1166C polymorphisms of the AT1R gene were determined.
Results.
Postprandial lipemia was significantly higher in homozygous carriers of the 1166-C allele (9.39±8.36 mM*h/L) compared to homozygous carriers of the 1166-A allele (2.02±6.20 mM*h/L) (P<0.05).
Postprandial lipemia was similar for the different C573T polymorphisms.
Conclusion.
The 1166-C allele of the AT1R gene seems to be associated with increased postprandial lipemia.
These data confirm the earlier described relationships between the renin-angiotensin axis and triglyceride metabolism.
American Psychological Association (APA)
Klop, Boudewijn& van den Berg, T. M.& Rietveld, A. P.& Chaves, J.& Real, J. T.& Ascaso, J. F.…[et al.]. 2011. AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-459166
Modern Language Association (MLA)
Klop, Boudewijn…[et al.]. AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia. International Journal of Vascular Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-459166
American Medical Association (AMA)
Klop, Boudewijn& van den Berg, T. M.& Rietveld, A. P.& Chaves, J.& Real, J. T.& Ascaso, J. F.…[et al.]. AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia. International Journal of Vascular Medicine. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-459166
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459166
