RUNX Family Participates in the Regulation of p53-Dependent DNA Damage Response
Joint Authors
Ozaki, Toshinori
Nagase, Hiroki
Nakagawara, Akira
Source
International Journal of Genomics
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
A proper DNA damage response (DDR), which monitors and maintains the genomic integrity, has been considered to be a critical barrier against genetic alterations to prevent tumor initiation and progression.
The representative tumor suppressor p53 plays an important role in the regulation of DNA damage response.
When cells receive DNA damage, p53 is quickly activated and induces cell cycle arrest and/or apoptotic cell death through transactivating its target genes implicated in the promotion of cell cycle arrest and/or apoptotic cell death such as p21WAF1, BAX, and PUMA.
Accumulating evidence strongly suggests that DNA damage-mediated activation as well as induction of p53 is regulated by posttranslational modifications and also by protein-protein interaction.
Loss of p53 activity confers growth advantage and ensures survival in cancer cells by inhibiting apoptotic response required for tumor suppression.
RUNX family, which is composed of RUNX1, RUNX2, and RUNX3, is a sequence-specific transcription factor and is closely involved in a variety of cellular processes including development, differentiation, and/or tumorigenesis.
In this review, we describe a background of p53 and a functional collaboration between p53 and RUNX family in response to DNA damage.
American Psychological Association (APA)
Ozaki, Toshinori& Nakagawara, Akira& Nagase, Hiroki. 2013. RUNX Family Participates in the Regulation of p53-Dependent DNA Damage Response. International Journal of Genomics،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-459184
Modern Language Association (MLA)
Ozaki, Toshinori…[et al.]. RUNX Family Participates in the Regulation of p53-Dependent DNA Damage Response. International Journal of Genomics No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-459184
American Medical Association (AMA)
Ozaki, Toshinori& Nakagawara, Akira& Nagase, Hiroki. RUNX Family Participates in the Regulation of p53-Dependent DNA Damage Response. International Journal of Genomics. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-459184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459184