Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice
Joint Authors
Langlois, Xavier
Kuijlaars, Jacobine
Ver Donck, Luc
Acton, Paul D.
Biesmans, Steven
De Haes, Patrick
Matthews, Liam J. R.
Hellings, Niels
Bouwknecht, Jan A.
Nuydens, Rony
Davoodi, Nima
Meert, Theo F.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-10
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Substantial evidence indicates an association between clinical depression and altered immune function.
Systemic administration of bacterial lipopolysaccharide (LPS) is commonly used to study inflammation-associated behavioral changes in rodents.
In these experiments, we tested the hypothesis that peripheral immune activation leads to neuroinflammation and depressive-like behavior in mice.
We report that systemic administration of LPS induced astrocyte activation in transgenic GFAP-luc mice and increased immunoreactivity against the microglial marker ionized calcium-binding adapter molecule 1 in the dentate gyrus of wild-type mice.
Furthermore, LPS treatment caused a strong but transient increase in cytokine levels in the serum and brain.
In addition to studying LPS-induced neuroinflammation, we tested whether sickness could be separated from depressive-like behavior by evaluating LPS-treated mice in a panel of behavioral paradigms.
Our behavioral data indicate that systemic LPS administration caused sickness and mild depressive-like behavior.
However, due to the overlapping time course and mild effects on depression-related behavior per se, it was not possible to separate sickness from depressive-like behavior in the present rodent model.
American Psychological Association (APA)
Biesmans, Steven& Meert, Theo F.& Bouwknecht, Jan A.& Acton, Paul D.& Davoodi, Nima& De Haes, Patrick…[et al.]. 2013. Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-459187
Modern Language Association (MLA)
Biesmans, Steven…[et al.]. Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice. Mediators of Inflammation No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-459187
American Medical Association (AMA)
Biesmans, Steven& Meert, Theo F.& Bouwknecht, Jan A.& Acton, Paul D.& Davoodi, Nima& De Haes, Patrick…[et al.]. Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-459187
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459187