![](/images/graphics-bg.png)
Rituximab Administration in Third Trimester of Pregnancy Suppresses Neonatal B-Cell Development
Joint Authors
Schreurs, M. W. J.
Klink, D. T.
van Well, G. T. J.
van Elburg, R. M.
Source
Clinical and Developmental Immunology
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-06-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We describe the effect on the neonate of administration of rituximab to a woman with idiopathic thrombocytopenic purpura (ITP).
Rituximab, an anti-CD20 antibody, was given weekly for 4 weeks to a woman with ITP in her third trimester of pregnancy.
One month after the last rituximab administration a healthy girl was born.
She had normal growth and development during the first six months.
At birth, B-lymphocytes were not detectable.
Rituximab levels in mother and neonate were 24000 and 6700 ng/mL, respectively.
Only 7 cases of rituximab administration during pregnancy were described.
No adverse events are described for fetus and neonate.
We demonstrate that rituximab passes the placenta and inhibits neonatal B-lymphocyte development.
However, after 6 months B-lymphocyte levels normalized and vaccination titres after 10 months were adequate.
No infection-related complications occurred.
Rituximab administration during pregnancy appears to be safe for the child but further studies are warranted.
American Psychological Association (APA)
Klink, D. T.& van Elburg, R. M.& Schreurs, M. W. J.& van Well, G. T. J.. 2008. Rituximab Administration in Third Trimester of Pregnancy Suppresses Neonatal B-Cell Development. Clinical and Developmental Immunology،Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-459188
Modern Language Association (MLA)
Klink, D. T.…[et al.]. Rituximab Administration in Third Trimester of Pregnancy Suppresses Neonatal B-Cell Development. Clinical and Developmental Immunology No. 2008 (2008), pp.1-6.
https://search.emarefa.net/detail/BIM-459188
American Medical Association (AMA)
Klink, D. T.& van Elburg, R. M.& Schreurs, M. W. J.& van Well, G. T. J.. Rituximab Administration in Third Trimester of Pregnancy Suppresses Neonatal B-Cell Development. Clinical and Developmental Immunology. 2008. Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-459188
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459188