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Lipid Metabolism and Cardiovascular Risk in HIV-1 Infection and HAART : Present and Future Problems
Joint Authors
Rizzardini, Giuliano
Passerini, Simone
Cossu, Maria Vittoria
Capetti, Amedeo
Carenzi, Laura
Melzi, Sara
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-31
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Many infections favor or are directly implicated with lipid metabolism perturbations and/or increased risk of coronary heart disease (CHD).
HIV itself has been shown to increase lipogenesis in the liver and to alter the lipid profile, while the presence of unsafe habits, addiction, comorbidities, and AIDS-related diseases increases substantially the risk of cardiovascular disease (CVD) in the HIV-infected population.
Antiretroviral therapy reduces such stimuli but many drugs have intrinsic toxicity profiles impacting on metabolism or potential direct cardiotoxicity.
In a moment when the main guidelines of HIV therapy are predating the point when to start treating, we mean to highlight the contribution of HIV-1 to lipid alteration and inflammation, the impact of antiretroviral therapy, the decisions on what drugs to use to reduce the probability of having a cardiovascular event, the increasing use of statins and fibrates in HIV-1 infected subjects, and finally the switch strategies, that balance effectiveness and toxicity to move the decision to change HIV drugs.
Early treatment might reduce the negative effect of HIV on overall cardiovascular risk but may also evidence the impact of drugs, and the final balance (reduction or increase in CHD and lipid abnormalities) is not known up to date.
American Psychological Association (APA)
Melzi, Sara& Carenzi, Laura& Cossu, Maria Vittoria& Passerini, Simone& Capetti, Amedeo& Rizzardini, Giuliano. 2010. Lipid Metabolism and Cardiovascular Risk in HIV-1 Infection and HAART : Present and Future Problems. Cholesterol،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-459203
Modern Language Association (MLA)
Melzi, Sara…[et al.]. Lipid Metabolism and Cardiovascular Risk in HIV-1 Infection and HAART : Present and Future Problems. Cholesterol No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-459203
American Medical Association (AMA)
Melzi, Sara& Carenzi, Laura& Cossu, Maria Vittoria& Passerini, Simone& Capetti, Amedeo& Rizzardini, Giuliano. Lipid Metabolism and Cardiovascular Risk in HIV-1 Infection and HAART : Present and Future Problems. Cholesterol. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-459203
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459203