![](/images/graphics-bg.png)
Natural Compounds as Modulators of NADPH Oxidases
Author
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Reactive oxygen species (ROS) are cellular signals generated ubiquitously by all mammalian cells, but their relative unbalance triggers also diseases through intracellular damage to DNA, RNA, proteins, and lipids.
NADPH oxidases (NOX) are the only known enzyme family with the sole function to produce ROS.
The NOX physiological functions concern host defence, cellular signaling, regulation of gene expression, and cell differentiation.
On the other hand, increased NOX activity contributes to a wide range of pathological processes, including cardiovascular diseases, neurodegeneration, organ failure, and cancer.
Therefore targeting these enzymatic ROS sources by natural compounds, without affecting the physiological redox state, may be an important tool.
This review summarizes the current state of knowledge of the role of NOX enzymes in physiology and pathology and provides an overview of the currently available NADPH oxidase inhibitors derived from natural extracts such as polyphenols.
American Psychological Association (APA)
Maraldi, Tullia. 2013. Natural Compounds as Modulators of NADPH Oxidases. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-459215
Modern Language Association (MLA)
Maraldi, Tullia. Natural Compounds as Modulators of NADPH Oxidases. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-459215
American Medical Association (AMA)
Maraldi, Tullia. Natural Compounds as Modulators of NADPH Oxidases. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-459215
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459215