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Murine Models of Systemic Lupus Erythematosus
Joint Authors
Sang, Allison
Morel, Laurence
Zheng, Ying-Yi
Yin, Yiming
Perry, Daniel
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-14
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder.
The study of diverse mouse models of lupus has provided clues to the etiology of SLE.
Spontaneous mouse models of lupus have led to identification of numerous susceptibility loci from which several candidate genes have emerged.
Meanwhile, induced models of lupus have provided insight into the role of environmental factors in lupus pathogenesis as well as provided a better understanding of cellular mechanisms involved in the onset and progression of disease.
The SLE-like phenotypes present in these models have also served to screen numerous potential SLE therapies.
Due to the complex nature of SLE, it is necessary to understand the effect specific targeted therapies have on immune homeostasis.
Furthermore, knowledge gained from mouse models will provide novel therapy targets for the treatment of SLE.
American Psychological Association (APA)
Perry, Daniel& Sang, Allison& Yin, Yiming& Zheng, Ying-Yi& Morel, Laurence. 2011. Murine Models of Systemic Lupus Erythematosus. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-19.
https://search.emarefa.net/detail/BIM-459223
Modern Language Association (MLA)
Perry, Daniel…[et al.]. Murine Models of Systemic Lupus Erythematosus. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-19.
https://search.emarefa.net/detail/BIM-459223
American Medical Association (AMA)
Perry, Daniel& Sang, Allison& Yin, Yiming& Zheng, Ying-Yi& Morel, Laurence. Murine Models of Systemic Lupus Erythematosus. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-19.
https://search.emarefa.net/detail/BIM-459223
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459223