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Lithium Toxicity and Neurologic Effects : Probable Neuroleptic Malignant Syndrome Resulting from Lithium Toxicity
Joint Authors
Fyyaz, Madiha
Edokpolo, Osamede
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-18
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Introduction.
We present the case of a patient who developed lithium toxicity with normal therapeutic levels, as a result of pharmacokinetic interaction with Valsartan, and probable Neuroleptic Malignant Syndrome from the ensuing lithium toxicity.
Case Presentation.
A 59-year old black male with bipolar disorder maintained on lithium and fluphenazine therapy presented with a 2 week history of worsening confusion, tremor, and gait abnormality.
He recently had his dose of Valsartan increased.
At presentation, patient had signs of autonomic instability, he was confused, dehydrated, and had rigidity of upper extremities.
Significant labs on admission were lithium level-1.2, elevated CK-6008, leukocytosis WBC-22, and renal impairment; Creatinine-4.1, BUN-35, HCO3-20.1, and blood glucose 145.
CT/MRI brain showed old cerebral infarcts, and there was no evidence of an infective process.
Lithium and fluphenazine were discontinued, his lithium levels gradually decreased, and he improved with supportive treatment including rehydration and correction of electrolyte imbalance.
Conclusions.
This case illustrates that lithium toxicity can occur within therapeutic levels, and the neurotoxic effect of lithium can include Neuroleptic Malignant Syndrome.
Clinicians should be aware of the risk associated with drug interactions with lithium.
American Psychological Association (APA)
Edokpolo, Osamede& Fyyaz, Madiha. 2012. Lithium Toxicity and Neurologic Effects : Probable Neuroleptic Malignant Syndrome Resulting from Lithium Toxicity. Case Reports in Psychiatry،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-459237
Modern Language Association (MLA)
Edokpolo, Osamede& Fyyaz, Madiha. Lithium Toxicity and Neurologic Effects : Probable Neuroleptic Malignant Syndrome Resulting from Lithium Toxicity. Case Reports in Psychiatry No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-459237
American Medical Association (AMA)
Edokpolo, Osamede& Fyyaz, Madiha. Lithium Toxicity and Neurologic Effects : Probable Neuroleptic Malignant Syndrome Resulting from Lithium Toxicity. Case Reports in Psychiatry. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-459237
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459237