The Inhibition of Lipase and Glucosidase Activities by Acacia Polyphenol
Joint Authors
Ito, Kiyomi
Takeda, Rumi
Ikarashi, Nobutomo
Sugiyama, Kiyoshi
Ochiai, Wataru
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Acacia polyphenol (AP) extracted from the bark of the black wattle tree (Acacia mearnsii) is rich in unique catechin-like flavan-3-ols, such as robinetinidol and fisetinidol.
In an in vitro study, we measured the inhibitory activity of AP on lipase and glucosidase.
In addition, we evaluated the effects of AP on absorption of orally administered olive oil, glucose, maltose, sucrose and starch solution in mice.
We found that AP concentration-dependently inhibited the activity of lipase, maltase and sucrase with an IC50 of 0.95, 0.22 and 0.60 mg ml−1, respectively.
In ICR mice, olive oil was administered orally immediately after oral administration of AP solution, and plasma triglyceride concentration was measured.
We found that AP significantly inhibited the rise in plasma triglyceride concentration after olive oil loading.
AP also significantly inhibited the rise in plasma glucose concentration after maltose and sucrose loading, and this effect was more potent against maltose.
AP also inhibited the rise in plasma glucose concentration after glucose loading and slightly inhibited it after starch loading.
Our results suggest that AP inhibits lipase and glucosidase activities, which leads to a reduction in the intestinal absorption of lipids and carbohydrates.
American Psychological Association (APA)
Ikarashi, Nobutomo& Takeda, Rumi& Ito, Kiyomi& Ochiai, Wataru& Sugiyama, Kiyoshi. 2011. The Inhibition of Lipase and Glucosidase Activities by Acacia Polyphenol. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-459257
Modern Language Association (MLA)
Ikarashi, Nobutomo…[et al.]. The Inhibition of Lipase and Glucosidase Activities by Acacia Polyphenol. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-459257
American Medical Association (AMA)
Ikarashi, Nobutomo& Takeda, Rumi& Ito, Kiyomi& Ochiai, Wataru& Sugiyama, Kiyoshi. The Inhibition of Lipase and Glucosidase Activities by Acacia Polyphenol. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-459257
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459257