Effective Treatment of Rheumatoid Arthritis-Associated Interstitial Lung Disease by B-Cell Targeted Therapy with Rituximab
Joint Authors
Maier, Judith
Pfeifer, Michael
Hartung, Wolfgang
Fleck, Martin
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-22
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Rheumatoid arthritis- (RA-) associated interstitial lung disease (RA-ILD) is the extra-articular complication with most adverse impact on the quality of life and survival in RA patients.
However, treatment options are limited and controlled studies are lacking.
Here, we present the case of a 66-year-old patient suffering from severe RA-ILD, which has been successfully treated with Rituximab (RTX).
After failure of conventional DMARD therapy, our patient showed sustained improvement of clinical pulmonary parameters as well as joint inflammation following B-cell depletion with RTX.
The six-minute-walk test improved from 380 meters to 536 meters and the forced vital capacity from 2.49 liters to 3.49.
The disease activity score could be reduced from 7.7 to 2.8.
Therefore, RTX might be considered as an alternative treatment for RA-ILD in patients not responding to conventional DMARD therapy.
American Psychological Association (APA)
Hartung, Wolfgang& Maier, Judith& Pfeifer, Michael& Fleck, Martin. 2012. Effective Treatment of Rheumatoid Arthritis-Associated Interstitial Lung Disease by B-Cell Targeted Therapy with Rituximab. Case Reports in Immunology،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-459274
Modern Language Association (MLA)
Hartung, Wolfgang…[et al.]. Effective Treatment of Rheumatoid Arthritis-Associated Interstitial Lung Disease by B-Cell Targeted Therapy with Rituximab. Case Reports in Immunology No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-459274
American Medical Association (AMA)
Hartung, Wolfgang& Maier, Judith& Pfeifer, Michael& Fleck, Martin. Effective Treatment of Rheumatoid Arthritis-Associated Interstitial Lung Disease by B-Cell Targeted Therapy with Rituximab. Case Reports in Immunology. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-459274
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459274