Intrathecal Administration of High-Titer Cytomegalovirus Immunoglobulin for Cytomegalovirus Meningitis
Joint Authors
Nagai, Tadashi
Muroi, Kazuo
Mori, Masaki
Ohmine, Ken
Ozawa, Keiya
Matsuyama, Tomohiro
Tatara, Raine
Fujiwara, Shin-ichiro
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-08
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Cytomegalovirus (CMV) central nervous system disease after hematopoietic stem cell transplantation (HSCT) is a rare but life-threatening complication.
Here, we report a patient who developed CMV meningitis after HSCT and was treated with the combination therapy of intrathecal high-titer CMV immunoglobulin and antiviral drugs.
A 38-year-old man with myelodysplastic syndrome received a cord blood transplant after graft failure.
On day 147, he was diagnosed with CMV meningitis based on pleocytosis and CMV DNA in the cerebrospinal fluid (CSF).
Intravenous ganciclovir, foscarnet, and immunoglobulin were administered; however, CMV DNA in the CSF was continuously detected.
The addition of intrathecal high-titer CMV immunoglobulin resulted in CMV DNA in the CSF becoming undetectable.
On day 241, CMV DNA in the CSF was detected again, but both intrathecal immunoglobulin and intravenous ganciclovir led to its disappearance.
No adverse effects related to intrathecal administration were observed.
The intrathecal administration of immunoglobulin may be safe and effective for CMV meningitis.
American Psychological Association (APA)
Fujiwara, Shin-ichiro& Muroi, Kazuo& Tatara, Raine& Ohmine, Ken& Matsuyama, Tomohiro& Mori, Masaki…[et al.]. 2014. Intrathecal Administration of High-Titer Cytomegalovirus Immunoglobulin for Cytomegalovirus Meningitis. Case Reports in Hematology،Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-459282
Modern Language Association (MLA)
Fujiwara, Shin-ichiro…[et al.]. Intrathecal Administration of High-Titer Cytomegalovirus Immunoglobulin for Cytomegalovirus Meningitis. Case Reports in Hematology No. 2014 (2014), pp.1-3.
https://search.emarefa.net/detail/BIM-459282
American Medical Association (AMA)
Fujiwara, Shin-ichiro& Muroi, Kazuo& Tatara, Raine& Ohmine, Ken& Matsuyama, Tomohiro& Mori, Masaki…[et al.]. Intrathecal Administration of High-Titer Cytomegalovirus Immunoglobulin for Cytomegalovirus Meningitis. Case Reports in Hematology. 2014. Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-459282
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459282