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Evolution of Autologous Chondrocyte Repair and Comparison to Other Cartilage Repair Techniques
Joint Authors
Trice, Michael E.
Gibson, Matthew A.
Dewan, Ashvin K.
Elisseeff, Jennifer H.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Articular cartilage defects have been addressed using microfracture, abrasion chondroplasty, or osteochondral grafting, but these strategies do not generate tissue that adequately recapitulates native cartilage.
During the past 25 years, promising new strategies using assorted scaffolds and cell sources to induce chondrocyte expansion have emerged.
We reviewed the evolution of autologous chondrocyte implantation and compared it to other cartilage repair techniques.
Methods.
We searched PubMed from 1949 to 2014 for the keywords “autologous chondrocyte implantation” (ACI) and “cartilage repair” in clinical trials, meta-analyses, and review articles.
We analyzed these articles, their bibliographies, our experience, and cartilage regeneration textbooks.
Results.
Microfracture, abrasion chondroplasty, osteochondral grafting, ACI, and autologous matrix-induced chondrogenesis are distinguishable by cell source (including chondrocytes and stem cells) and associated scaffolds (natural or synthetic, hydrogels or membranes).
ACI seems to be as good as, if not better than, microfracture for repairing large chondral defects in a young patient’s knee as evaluated by multiple clinical indices and the quality of regenerated tissue.
Conclusion.
Although there is not enough evidence to determine the best repair technique, ACI is the most established cell-based treatment for full-thickness chondral defects in young patients.
American Psychological Association (APA)
Dewan, Ashvin K.& Gibson, Matthew A.& Elisseeff, Jennifer H.& Trice, Michael E.. 2014. Evolution of Autologous Chondrocyte Repair and Comparison to Other Cartilage Repair Techniques. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-459284
Modern Language Association (MLA)
Dewan, Ashvin K.…[et al.]. Evolution of Autologous Chondrocyte Repair and Comparison to Other Cartilage Repair Techniques. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-459284
American Medical Association (AMA)
Dewan, Ashvin K.& Gibson, Matthew A.& Elisseeff, Jennifer H.& Trice, Michael E.. Evolution of Autologous Chondrocyte Repair and Comparison to Other Cartilage Repair Techniques. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-459284
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459284