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Mechanisms of Action of Indigenous Antidiabetic Plants from the Boreal Forest of Northeastern Canada
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Indigenous populations in Canada possess a wealth of native traditional knowledge.
However, their rates of Type 2 diabetes mellitus (T2DM), a disease that was unheard of in their midst 50 years ago, are the highest in the country.
In an effort to cut the impact of T2DM epidemic on Indigenous health, the Canadian Institutes of Health Research funded the “CIHR Team in Aboriginal Antidiabetic Medicines (CIHR-TAAM).” The goal was to explore Boreal forest medicinal plants stemming from Indigenous Traditional Medicine to be included in T2DM care.
Six out of nine communities of the Cree of Eeyou Istchee (CEI) participated in ethnobotanical studies that resulted in the identification of 17 potential antidiabetic plant species.
These species were screened for antidiabetic activities using a platform of in vitro bioassays and in vivo models of T2DM.
This paper summarizes results on the 10 most promising plant species, their active constituents, and the mechanisms behind their antidiabetic activities.
In addition, potential herb-drug interactions were examined at the level of drug-metabolizing enzymes, notably the cytochrome P450 family.
This review serves as a canvas onto which is discussed the value of Indigenous medicinal plants, future avenues of research, and the ethical approach required in this field.
American Psychological Association (APA)
Eid, Hoda M.& Haddad, Pierre S.. 2014. Mechanisms of Action of Indigenous Antidiabetic Plants from the Boreal Forest of Northeastern Canada. Advances in Endocrinology،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-459337
Modern Language Association (MLA)
Eid, Hoda M.& Haddad, Pierre S.. Mechanisms of Action of Indigenous Antidiabetic Plants from the Boreal Forest of Northeastern Canada. Advances in Endocrinology No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-459337
American Medical Association (AMA)
Eid, Hoda M.& Haddad, Pierre S.. Mechanisms of Action of Indigenous Antidiabetic Plants from the Boreal Forest of Northeastern Canada. Advances in Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-459337
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459337