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Potential Clinical Applications for Human Pluripotent Stem Cell-Derived Blood Components
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
The ability of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) to divide indefinitely without losing pluripotency and to theoretically differentiate into any cell type in the body makes them highly attractive cell sources for large scale regenerative medicine purposes.
The current use of adult stem cell-derived products in hematologic intervention sets an important precedent and provides a guide for developing hESC/iPSC based therapies for the blood system.
In this review, we highlight biological functions of mature cells of the blood, clinical conditions requiring the transfusion or stimulation of these cells, and the potential for hESC/iPSC-derivatives to serve as functional replacements.
Many researchers have already been able to differentiate hESCs and/or iPSCs into specific mature blood cell types.
For example, hESC-derived red blood cells and platelets are functional in tasks such as oxygen delivery and blood clotting, respectively and may be able to serve as substitutes for their donor-derived counterparts in emergencies.
hESC-derived dendritic cells are functional in antigen-presentation and may be used as off-the-shelf vaccine therapies to stimulate antigen-specific immune responses against cancer cells.
However, in vitro differentiation systems used to generate these cells will need further optimization before hESC/iPSC-derived blood components can be used clinically.
American Psychological Association (APA)
Kimbrel, Erin A.& Lu, Shi-Jiang. 2011. Potential Clinical Applications for Human Pluripotent Stem Cell-Derived Blood Components. Stem Cells International،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-459347
Modern Language Association (MLA)
Kimbrel, Erin A.& Lu, Shi-Jiang. Potential Clinical Applications for Human Pluripotent Stem Cell-Derived Blood Components. Stem Cells International No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-459347
American Medical Association (AMA)
Kimbrel, Erin A.& Lu, Shi-Jiang. Potential Clinical Applications for Human Pluripotent Stem Cell-Derived Blood Components. Stem Cells International. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-459347
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459347