Autophagy in Drosophila : From Historical Studies to Current Knowledge

Joint Authors

Takats, Szabolcs
Juhász, Gábor
Tusco, Radu
Nezis, Ioannis P.
Mulakkal, Nitha C.
Nagy, Péter

Source

BioMed Research International

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-24, 24 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-05-18

Country of Publication

Egypt

No. of Pages

24

Main Subjects

Medicine

Abstract EN

The discovery of evolutionarily conserved Atg genes required for autophagy in yeast truly revolutionized this research field and made it possible to carry out functional studies on model organisms.

Insects including Drosophila are classical and still popular models to study autophagy, starting from the 1960s.

This review aims to summarize past achievements and our current knowledge about the role and regulation of autophagy in Drosophila, with an outlook to yeast and mammals.

The basic mechanisms of autophagy in fruit fly cells appear to be quite similar to other eukaryotes, and the role that this lysosomal self-degradation process plays in Drosophila models of various diseases already made it possible to recognize certain aspects of human pathologies.

Future studies in this complete animal hold great promise for the better understanding of such processes and may also help finding new research avenues for the treatment of disorders with misregulated autophagy.

American Psychological Association (APA)

Mulakkal, Nitha C.& Nagy, Péter& Takats, Szabolcs& Tusco, Radu& Juhász, Gábor& Nezis, Ioannis P.. 2014. Autophagy in Drosophila : From Historical Studies to Current Knowledge. BioMed Research International،Vol. 2014, no. 2014, pp.1-24.
https://search.emarefa.net/detail/BIM-459379

Modern Language Association (MLA)

Mulakkal, Nitha C.…[et al.]. Autophagy in Drosophila : From Historical Studies to Current Knowledge. BioMed Research International No. 2014 (2014), pp.1-24.
https://search.emarefa.net/detail/BIM-459379

American Medical Association (AMA)

Mulakkal, Nitha C.& Nagy, Péter& Takats, Szabolcs& Tusco, Radu& Juhász, Gábor& Nezis, Ioannis P.. Autophagy in Drosophila : From Historical Studies to Current Knowledge. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-24.
https://search.emarefa.net/detail/BIM-459379

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-459379