Autophagy in Drosophila : From Historical Studies to Current Knowledge
Joint Authors
Takats, Szabolcs
Juhász, Gábor
Tusco, Radu
Nezis, Ioannis P.
Mulakkal, Nitha C.
Nagy, Péter
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Abstract EN
The discovery of evolutionarily conserved Atg genes required for autophagy in yeast truly revolutionized this research field and made it possible to carry out functional studies on model organisms.
Insects including Drosophila are classical and still popular models to study autophagy, starting from the 1960s.
This review aims to summarize past achievements and our current knowledge about the role and regulation of autophagy in Drosophila, with an outlook to yeast and mammals.
The basic mechanisms of autophagy in fruit fly cells appear to be quite similar to other eukaryotes, and the role that this lysosomal self-degradation process plays in Drosophila models of various diseases already made it possible to recognize certain aspects of human pathologies.
Future studies in this complete animal hold great promise for the better understanding of such processes and may also help finding new research avenues for the treatment of disorders with misregulated autophagy.
American Psychological Association (APA)
Mulakkal, Nitha C.& Nagy, Péter& Takats, Szabolcs& Tusco, Radu& Juhász, Gábor& Nezis, Ioannis P.. 2014. Autophagy in Drosophila : From Historical Studies to Current Knowledge. BioMed Research International،Vol. 2014, no. 2014, pp.1-24.
https://search.emarefa.net/detail/BIM-459379
Modern Language Association (MLA)
Mulakkal, Nitha C.…[et al.]. Autophagy in Drosophila : From Historical Studies to Current Knowledge. BioMed Research International No. 2014 (2014), pp.1-24.
https://search.emarefa.net/detail/BIM-459379
American Medical Association (AMA)
Mulakkal, Nitha C.& Nagy, Péter& Takats, Szabolcs& Tusco, Radu& Juhász, Gábor& Nezis, Ioannis P.. Autophagy in Drosophila : From Historical Studies to Current Knowledge. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-24.
https://search.emarefa.net/detail/BIM-459379
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459379