The Kinetics of Ampicillin Release from Hydroxyapatite for Bones Regeneration
Joint Authors
Ferreira, Andrea Lopes de Oliveira
da Silva, Giovanilton Ferreira
de Oliveira, Caroliny Gomes
Nogueira, Ricardo Emilio Ferreira Quevedo
Albuquerque, José Sílvio Veras
Source
International Journal of Chemical Engineering
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Engineering Sciences and Information Technology
Abstract EN
Semisynthetic beta-lactam antibiotics are among the most used pharmaceuticals.
Their use in veterinary and human medicine is in continuous expansion.
There is a growing need for developing bioactive implants.
Advantages of implantable drug delivery tools can include high release efficiency, precise dose control, low toxicity, and allow to overcome disadvantages connected with conventional methods.
In this respect, hydroxyapatite (HA) is an elective material.
It enables to produce architectures similar to those of real bones.
Here we studied a kinetic model to describe ampicillin release from HA.
In the course of adsorption experiment, ampicillin was dissolved, maintained at 30∘C and shaken at 60 strokes/minute.
Samples were withdrawn periodically for analysis and then returned to the mixture.
Adsorbed amounts were measured by the difference of the concentration of the antibiotics before and after adsorption using UV adsorption at 225 nm.
The aim of this work was to evaluate its application as ampicillin delivery carrier.
American Psychological Association (APA)
da Silva, Giovanilton Ferreira& Albuquerque, José Sílvio Veras& de Oliveira, Caroliny Gomes& Nogueira, Ricardo Emilio Ferreira Quevedo& Ferreira, Andrea Lopes de Oliveira. 2009. The Kinetics of Ampicillin Release from Hydroxyapatite for Bones Regeneration. International Journal of Chemical Engineering،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-459413
Modern Language Association (MLA)
da Silva, Giovanilton Ferreira…[et al.]. The Kinetics of Ampicillin Release from Hydroxyapatite for Bones Regeneration. International Journal of Chemical Engineering No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-459413
American Medical Association (AMA)
da Silva, Giovanilton Ferreira& Albuquerque, José Sílvio Veras& de Oliveira, Caroliny Gomes& Nogueira, Ricardo Emilio Ferreira Quevedo& Ferreira, Andrea Lopes de Oliveira. The Kinetics of Ampicillin Release from Hydroxyapatite for Bones Regeneration. International Journal of Chemical Engineering. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-459413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459413