Activation of Type I Interferon Pathway in Systemic Lupus Erythematosus : Association with Distinct Clinical Phenotypes
Joint Authors
Karageorgas, Theophanis P.
Tseronis, Dimitrios D.
Mavragani, Clio P.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Growing evidence over the last few years suggests a central role of type I IFN pathway in the pathogenesis of systemic autoimmune disorders.
Data from clinical and genetic studies in patients with systemic lupus erythematosus (SLE) and lupus-prone mouse models, indicates that the type I interferon system may play a pivotal role in the pathogenesis of several lupus and associated clinical features, such as nephritis, neuropsychiatric and cutaneous lupus, premature atherosclerosis as well as lupus-specific autoantibodies particularly against ribonucleoproteins.
In the current paper, our aim is to summarize the latest findings supporting the association of type I IFN pathway with specific clinical manifestations in the setting of SLE providing insights on the potential use of type I IFN as a therapeutic target.
American Psychological Association (APA)
Karageorgas, Theophanis P.& Tseronis, Dimitrios D.& Mavragani, Clio P.. 2011. Activation of Type I Interferon Pathway in Systemic Lupus Erythematosus : Association with Distinct Clinical Phenotypes. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-459419
Modern Language Association (MLA)
Karageorgas, Theophanis P.…[et al.]. Activation of Type I Interferon Pathway in Systemic Lupus Erythematosus : Association with Distinct Clinical Phenotypes. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-459419
American Medical Association (AMA)
Karageorgas, Theophanis P.& Tseronis, Dimitrios D.& Mavragani, Clio P.. Activation of Type I Interferon Pathway in Systemic Lupus Erythematosus : Association with Distinct Clinical Phenotypes. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-459419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459419